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SMILES: CN1C(=O)Nc2cc(Cl)c(Cl)cc2C11NC(=O)NC1=O

InChI Key: InChIKey=DRJQSCFUISAEGH-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50006370   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Aldo-keto reductase family 1 member B1


(Homo sapiens (Human))		BDBM50006370
PNG
(6',7'-dichloro-3'-methyl-1'H,2H,5H-spiro[imidazoli...)
Show SMILES CN1C(=O)Nc2cc(Cl)c(Cl)cc2C11NC(=O)NC1=O
Show InChI InChI=1S/C11H8Cl2N4O3/c1-17-10(20)14-7-3-6(13)5(12)2-4(7)11(17)8(18)15-9(19)16-11/h2-3H,1H3,(H,14,20)(H2,15,16,18,19)
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n/an/a 74n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens

J Med Chem 35: 2085-94 (1992)


BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair