BDBM50006819 2-(4-Benzyloxy-phenyl)-N-hydroxy-N-phenethyl-acetamide::CHEMBL52748::RG-6820

SMILES: ON(CCc1ccccc1)C(=O)Cc1ccc(OCc2ccccc2)cc1

InChI Key: InChIKey=CCBFWYRWDWBCOM-UHFFFAOYSA-N

Data: 2 KI  5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50006819   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50006819 (2-(4-Benzyloxy-phenyl)-N-hydroxy-N-phenethyl-aceta...) Show SMILES ON(CCc1ccccc1)C(=O)Cc1ccc(OCc2ccccc2)cc1 Show InChI InChI=1S/C23H23NO3/c25-23(24(26)16-15-19-7-3-1-4-8-19)17-20-11-13-22(14-12-20)27-18-21-9-5-2-6-10-21/h1-14,26H,15-18H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rorer Central Research Curated by ChEMBL					Assay Description Invitro inhibitory activity against polymorphonuclear leukocyte 5-lipoxygenase in human cell				J Med Chem 32: 1836-42 (1989) BindingDB Entry DOI: 10.7270/Q2VT1R21
					More data for this Ligand-Target Pair
Arachidonate 12-lipoxygenase (Rattus norvegicus)	BDBM50006819 (2-(4-Benzyloxy-phenyl)-N-hydroxy-N-phenethyl-aceta...) Show SMILES ON(CCc1ccccc1)C(=O)Cc1ccc(OCc2ccccc2)cc1 Show InChI InChI=1S/C23H23NO3/c25-23(24(26)16-15-19-7-3-1-4-8-19)17-20-11-13-22(14-12-20)27-18-21-9-5-2-6-10-21/h1-14,26H,15-18H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rorer Central Research Curated by ChEMBL					Assay Description In vitro inhibitory activity against rat platelet 12-lipoxygenase				J Med Chem 32: 1836-42 (1989) BindingDB Entry DOI: 10.7270/Q2VT1R21
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50006819 (2-(4-Benzyloxy-phenyl)-N-hydroxy-N-phenethyl-aceta...) Show SMILES ON(CCc1ccccc1)C(=O)Cc1ccc(OCc2ccccc2)cc1 Show InChI InChI=1S/C23H23NO3/c25-23(24(26)16-15-19-7-3-1-4-8-19)17-20-11-13-22(14-12-20)27-18-21-9-5-2-6-10-21/h1-14,26H,15-18H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Rorer Central Research Curated by ChEMBL					Assay Description Inhibitory activity against polymorphonuclear leukocyte 5-lipoxygenase using guinea pig supernatant				J Med Chem 32: 1836-42 (1989) BindingDB Entry DOI: 10.7270/Q2VT1R21
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50006819 (2-(4-Benzyloxy-phenyl)-N-hydroxy-N-phenethyl-aceta...) Show SMILES ON(CCc1ccccc1)C(=O)Cc1ccc(OCc2ccccc2)cc1 Show InChI InChI=1S/C23H23NO3/c25-23(24(26)16-15-19-7-3-1-4-8-19)17-20-11-13-22(14-12-20)27-18-21-9-5-2-6-10-21/h1-14,26H,15-18H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Rorer Central Research Curated by ChEMBL					Assay Description In vitro inhibition of polymorphonuclear leukocyte derived human 5-lipoxygenase				J Med Chem 32: 1836-42 (1989) BindingDB Entry DOI: 10.7270/Q2VT1R21
					More data for this Ligand-Target Pair
Arachidonate 12-lipoxygenase (Rattus norvegicus)	BDBM50006819 (2-(4-Benzyloxy-phenyl)-N-hydroxy-N-phenethyl-aceta...) Show SMILES ON(CCc1ccccc1)C(=O)Cc1ccc(OCc2ccccc2)cc1 Show InChI InChI=1S/C23H23NO3/c25-23(24(26)16-15-19-7-3-1-4-8-19)17-20-11-13-22(14-12-20)27-18-21-9-5-2-6-10-21/h1-14,26H,15-18H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Rorer Central Research Curated by ChEMBL					Assay Description Invitro inhibition of rat platelet 12-lipoxygenase				J Med Chem 32: 1836-42 (1989) BindingDB Entry DOI: 10.7270/Q2VT1R21
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50006819 (2-(4-Benzyloxy-phenyl)-N-hydroxy-N-phenethyl-aceta...) Show SMILES ON(CCc1ccccc1)C(=O)Cc1ccc(OCc2ccccc2)cc1 Show InChI InChI=1S/C23H23NO3/c25-23(24(26)16-15-19-7-3-1-4-8-19)17-20-11-13-22(14-12-20)27-18-21-9-5-2-6-10-21/h1-14,26H,15-18H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
Rorer Central Research Curated by ChEMBL					Assay Description In vitro inhibition of rat polymorphonuclear leukocyte 5-lipoxygenase				J Med Chem 32: 1836-42 (1989) BindingDB Entry DOI: 10.7270/Q2VT1R21
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50006819 (2-(4-Benzyloxy-phenyl)-N-hydroxy-N-phenethyl-aceta...) Show SMILES ON(CCc1ccccc1)C(=O)Cc1ccc(OCc2ccccc2)cc1 Show InChI InChI=1S/C23H23NO3/c25-23(24(26)16-15-19-7-3-1-4-8-19)17-20-11-13-22(14-12-20)27-18-21-9-5-2-6-10-21/h1-14,26H,15-18H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description The compound was tested for inhibitory activity against 5-Lipoxygenase in human polymorphonuclear leukocytes[PMNS]				J Med Chem 35: 2501-24 (1992) BindingDB Entry DOI: 10.7270/Q23B60R4
					More data for this Ligand-Target Pair