BDBM50007040 2-[1-Methoxy-6-(naphthalen-2-ylmethoxy)-indan-1-yl]-thiazole::CHEMBL20953

SMILES: COC1(CCc2ccc(OCc3ccc4ccccc4c3)cc12)c1nccs1

InChI Key: InChIKey=PHWUGPWQJTXVQO-UHFFFAOYSA-N

Data: 12 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50007040   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50007040 (2-[1-Methoxy-6-(naphthalen-2-ylmethoxy)-indan-1-yl...) Show SMILES COC1(CCc2ccc(OCc3ccc4ccccc4c3)cc12)c1nccs1 Show InChI InChI=1S/C24H21NO2S/c1-26-24(23-25-12-13-28-23)11-10-19-8-9-21(15-22(19)24)27-16-17-6-7-18-4-2-3-5-20(18)14-17/h2-9,12-15H,10-11,16H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
ICI Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in human whole blood.				J Med Chem 34: 2176-86 (1991) BindingDB Entry DOI: 10.7270/Q2S46QX6
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Mus musculus)	BDBM50007040 (2-[1-Methoxy-6-(naphthalen-2-ylmethoxy)-indan-1-yl...) Show SMILES COC1(CCc2ccc(OCc3ccc4ccccc4c3)cc12)c1nccs1 Show InChI InChI=1S/C24H21NO2S/c1-26-24(23-25-12-13-28-23)11-10-19-8-9-21(15-22(19)24)27-16-17-6-7-18-4-2-3-5-20(18)14-17/h2-9,12-15H,10-11,16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
ICI Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in mouse macrophages.				J Med Chem 34: 2176-86 (1991) BindingDB Entry DOI: 10.7270/Q2S46QX6
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50007040 (2-[1-Methoxy-6-(naphthalen-2-ylmethoxy)-indan-1-yl...) Show SMILES COC1(CCc2ccc(OCc3ccc4ccccc4c3)cc12)c1nccs1 Show InChI InChI=1S/C24H21NO2S/c1-26-24(23-25-12-13-28-23)11-10-19-8-9-21(15-22(19)24)27-16-17-6-7-18-4-2-3-5-20(18)14-17/h2-9,12-15H,10-11,16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
ICI Pharmaceuticals Curated by ChEMBL					Assay Description Compound was tested for the inhibition of 5-lipoxygenase (5-LPO) in rat basophilic leukemia (RBL) cells.				J Med Chem 34: 2176-86 (1991) BindingDB Entry DOI: 10.7270/Q2S46QX6
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50007040 (2-[1-Methoxy-6-(naphthalen-2-ylmethoxy)-indan-1-yl...) Show SMILES COC1(CCc2ccc(OCc3ccc4ccccc4c3)cc12)c1nccs1 Show InChI InChI=1S/C24H21NO2S/c1-26-24(23-25-12-13-28-23)11-10-19-8-9-21(15-22(19)24)27-16-17-6-7-18-4-2-3-5-20(18)14-17/h2-9,12-15H,10-11,16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
ICI Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in human whole blood.				J Med Chem 34: 2176-86 (1991) BindingDB Entry DOI: 10.7270/Q2S46QX6
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50007040 (2-[1-Methoxy-6-(naphthalen-2-ylmethoxy)-indan-1-yl...) Show SMILES COC1(CCc2ccc(OCc3ccc4ccccc4c3)cc12)c1nccs1 Show InChI InChI=1S/C24H21NO2S/c1-26-24(23-25-12-13-28-23)11-10-19-8-9-21(15-22(19)24)27-16-17-6-7-18-4-2-3-5-20(18)14-17/h2-9,12-15H,10-11,16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
ICI Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in human whole blood.				J Med Chem 34: 2176-86 (1991) BindingDB Entry DOI: 10.7270/Q2S46QX6
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50007040 (2-[1-Methoxy-6-(naphthalen-2-ylmethoxy)-indan-1-yl...) Show SMILES COC1(CCc2ccc(OCc3ccc4ccccc4c3)cc12)c1nccs1 Show InChI InChI=1S/C24H21NO2S/c1-26-24(23-25-12-13-28-23)11-10-19-8-9-21(15-22(19)24)27-16-17-6-7-18-4-2-3-5-20(18)14-17/h2-9,12-15H,10-11,16H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase from human whole blood				J Med Chem 37: 113-24 (1994) BindingDB Entry DOI: 10.7270/Q2JW8CZP
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Mus musculus)	BDBM50007040 (2-[1-Methoxy-6-(naphthalen-2-ylmethoxy)-indan-1-yl...) Show SMILES COC1(CCc2ccc(OCc3ccc4ccccc4c3)cc12)c1nccs1 Show InChI InChI=1S/C24H21NO2S/c1-26-24(23-25-12-13-28-23)11-10-19-8-9-21(15-22(19)24)27-16-17-6-7-18-4-2-3-5-20(18)14-17/h2-9,12-15H,10-11,16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
ICI Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in mouse macrophages.				J Med Chem 34: 2176-86 (1991) BindingDB Entry DOI: 10.7270/Q2S46QX6
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50007040 (2-[1-Methoxy-6-(naphthalen-2-ylmethoxy)-indan-1-yl...) Show SMILES COC1(CCc2ccc(OCc3ccc4ccccc4c3)cc12)c1nccs1 Show InChI InChI=1S/C24H21NO2S/c1-26-24(23-25-12-13-28-23)11-10-19-8-9-21(15-22(19)24)27-16-17-6-7-18-4-2-3-5-20(18)14-17/h2-9,12-15H,10-11,16H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
ICI Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in human whole blood.				J Med Chem 34: 2176-86 (1991) BindingDB Entry DOI: 10.7270/Q2S46QX6
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50007040 (2-[1-Methoxy-6-(naphthalen-2-ylmethoxy)-indan-1-yl...) Show SMILES COC1(CCc2ccc(OCc3ccc4ccccc4c3)cc12)c1nccs1 Show InChI InChI=1S/C24H21NO2S/c1-26-24(23-25-12-13-28-23)11-10-19-8-9-21(15-22(19)24)27-16-17-6-7-18-4-2-3-5-20(18)14-17/h2-9,12-15H,10-11,16H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
ICI Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in human whole blood.				J Med Chem 34: 2176-86 (1991) BindingDB Entry DOI: 10.7270/Q2S46QX6
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Mus musculus)	BDBM50007040 (2-[1-Methoxy-6-(naphthalen-2-ylmethoxy)-indan-1-yl...) Show SMILES COC1(CCc2ccc(OCc3ccc4ccccc4c3)cc12)c1nccs1 Show InChI InChI=1S/C24H21NO2S/c1-26-24(23-25-12-13-28-23)11-10-19-8-9-21(15-22(19)24)27-16-17-6-7-18-4-2-3-5-20(18)14-17/h2-9,12-15H,10-11,16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.25E+3	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Inhibitory concentration of the compound against 5-lipoxygenase from mouse macrophage				J Med Chem 37: 113-24 (1994) BindingDB Entry DOI: 10.7270/Q2JW8CZP
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50007040 (2-[1-Methoxy-6-(naphthalen-2-ylmethoxy)-indan-1-yl...) Show SMILES COC1(CCc2ccc(OCc3ccc4ccccc4c3)cc12)c1nccs1 Show InChI InChI=1S/C24H21NO2S/c1-26-24(23-25-12-13-28-23)11-10-19-8-9-21(15-22(19)24)27-16-17-6-7-18-4-2-3-5-20(18)14-17/h2-9,12-15H,10-11,16H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase from human whole blood				J Med Chem 37: 113-24 (1994) BindingDB Entry DOI: 10.7270/Q2JW8CZP
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Mus musculus)	BDBM50007040 (2-[1-Methoxy-6-(naphthalen-2-ylmethoxy)-indan-1-yl...) Show SMILES COC1(CCc2ccc(OCc3ccc4ccccc4c3)cc12)c1nccs1 Show InChI InChI=1S/C24H21NO2S/c1-26-24(23-25-12-13-28-23)11-10-19-8-9-21(15-22(19)24)27-16-17-6-7-18-4-2-3-5-20(18)14-17/h2-9,12-15H,10-11,16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
ICI Pharmaceuticals Curated by ChEMBL					Assay Description Compound was tested for the inhibition of 5-lipoxygenase (5-LPO) in rat basophilic leukemia (RBL) cells.				J Med Chem 34: 2176-86 (1991) BindingDB Entry DOI: 10.7270/Q2S46QX6
					More data for this Ligand-Target Pair