Found 4 hits for monomerid = 50007218 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glucagon receptor
(Homo sapiens (Human)) | BDBM50007218
(CHEMBL3237928)Show SMILES CC(C)CC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cc(Cl)cc(Cl)c1)c1ccc(cc1)C(=O)NCc1nn[nH]n1 |r,wU:14.18,5.4,wD:11.12,c:9,(30.64,-43.26,;30.62,-41.72,;29.28,-40.97,;31.95,-40.94,;31.93,-39.4,;33.25,-38.61,;33.2,-37.07,;34.41,-36.12,;35.89,-36.54,;33.88,-34.68,;32.34,-34.74,;31.92,-36.21,;30.73,-35.23,;29.29,-35.76,;29.02,-37.28,;30.21,-38.26,;31.66,-37.73,;27.59,-37.81,;26.4,-36.82,;26.14,-38.34,;27.32,-39.33,;34.66,-33.35,;33.89,-32.01,;34.67,-30.68,;33.9,-29.34,;36.21,-30.69,;36.97,-32.03,;38.51,-32.04,;36.2,-33.36,;34.58,-39.39,;34.56,-40.94,;35.88,-41.72,;37.23,-40.97,;37.25,-39.43,;35.92,-38.65,;38.55,-41.76,;38.53,-43.3,;39.89,-41.01,;41.22,-41.79,;42.56,-41.04,;43.95,-41.68,;45,-40.54,;44.24,-39.2,;42.73,-39.51,)| Show InChI InChI=1S/C33H41Cl2N7O2/c1-20(2)6-11-27(21-7-9-22(10-8-21)30(43)36-19-28-38-40-41-39-28)42-31(44)29(23-16-25(34)18-26(35)17-23)37-33(42)14-12-24(13-15-33)32(3,4)5/h7-10,16-18,20,24,27H,6,11-15,19H2,1-5H3,(H,36,43)(H,38,39,40,41)/t24-,27-,33-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysis |
J Med Chem 57: 2601-10 (2014)
Article DOI: 10.1021/jm401858f
BindingDB Entry DOI: 10.7270/Q20V8F9P |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor (GLP-1)
(Homo sapiens (Human)) | BDBM50007218
(CHEMBL3237928)Show SMILES CC(C)CC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cc(Cl)cc(Cl)c1)c1ccc(cc1)C(=O)NCc1nn[nH]n1 |r,wU:14.18,5.4,wD:11.12,c:9,(30.64,-43.26,;30.62,-41.72,;29.28,-40.97,;31.95,-40.94,;31.93,-39.4,;33.25,-38.61,;33.2,-37.07,;34.41,-36.12,;35.89,-36.54,;33.88,-34.68,;32.34,-34.74,;31.92,-36.21,;30.73,-35.23,;29.29,-35.76,;29.02,-37.28,;30.21,-38.26,;31.66,-37.73,;27.59,-37.81,;26.4,-36.82,;26.14,-38.34,;27.32,-39.33,;34.66,-33.35,;33.89,-32.01,;34.67,-30.68,;33.9,-29.34,;36.21,-30.69,;36.97,-32.03,;38.51,-32.04,;36.2,-33.36,;34.58,-39.39,;34.56,-40.94,;35.88,-41.72,;37.23,-40.97,;37.25,-39.43,;35.92,-38.65,;38.55,-41.76,;38.53,-43.3,;39.89,-41.01,;41.22,-41.79,;42.56,-41.04,;43.95,-41.68,;45,-40.54,;44.24,-39.2,;42.73,-39.51,)| Show InChI InChI=1S/C33H41Cl2N7O2/c1-20(2)6-11-27(21-7-9-22(10-8-21)30(43)36-19-28-38-40-41-39-28)42-31(44)29(23-16-25(34)18-26(35)17-23)37-33(42)14-12-24(13-15-33)32(3,4)5/h7-10,16-18,20,24,27H,6,11-15,19H2,1-5H3,(H,36,43)(H,38,39,40,41)/t24-,27-,33-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human GLP-1R expressed in CHO cells assessed as inhibition of GLP-1-stimulated cAMP production preincubated for 30 mins follow... |
J Med Chem 57: 2601-10 (2014)
Article DOI: 10.1021/jm401858f
BindingDB Entry DOI: 10.7270/Q20V8F9P |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50007218
(CHEMBL3237928)Show SMILES CC(C)CC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cc(Cl)cc(Cl)c1)c1ccc(cc1)C(=O)NCc1nn[nH]n1 |r,wU:14.18,5.4,wD:11.12,c:9,(30.64,-43.26,;30.62,-41.72,;29.28,-40.97,;31.95,-40.94,;31.93,-39.4,;33.25,-38.61,;33.2,-37.07,;34.41,-36.12,;35.89,-36.54,;33.88,-34.68,;32.34,-34.74,;31.92,-36.21,;30.73,-35.23,;29.29,-35.76,;29.02,-37.28,;30.21,-38.26,;31.66,-37.73,;27.59,-37.81,;26.4,-36.82,;26.14,-38.34,;27.32,-39.33,;34.66,-33.35,;33.89,-32.01,;34.67,-30.68,;33.9,-29.34,;36.21,-30.69,;36.97,-32.03,;38.51,-32.04,;36.2,-33.36,;34.58,-39.39,;34.56,-40.94,;35.88,-41.72,;37.23,-40.97,;37.25,-39.43,;35.92,-38.65,;38.55,-41.76,;38.53,-43.3,;39.89,-41.01,;41.22,-41.79,;42.56,-41.04,;43.95,-41.68,;45,-40.54,;44.24,-39.2,;42.73,-39.51,)| Show InChI InChI=1S/C33H41Cl2N7O2/c1-20(2)6-11-27(21-7-9-22(10-8-21)30(43)36-19-28-38-40-41-39-28)42-31(44)29(23-16-25(34)18-26(35)17-23)37-33(42)14-12-24(13-15-33)32(3,4)5/h7-10,16-18,20,24,27H,6,11-15,19H2,1-5H3,(H,36,43)(H,38,39,40,41)/t24-,27-,33-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-stimulated cAMP production preincubated for 30 mins follo... |
J Med Chem 57: 2601-10 (2014)
Article DOI: 10.1021/jm401858f
BindingDB Entry DOI: 10.7270/Q20V8F9P |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Mus musculus) | BDBM50007218
(CHEMBL3237928)Show SMILES CC(C)CC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cc(Cl)cc(Cl)c1)c1ccc(cc1)C(=O)NCc1nn[nH]n1 |r,wU:14.18,5.4,wD:11.12,c:9,(30.64,-43.26,;30.62,-41.72,;29.28,-40.97,;31.95,-40.94,;31.93,-39.4,;33.25,-38.61,;33.2,-37.07,;34.41,-36.12,;35.89,-36.54,;33.88,-34.68,;32.34,-34.74,;31.92,-36.21,;30.73,-35.23,;29.29,-35.76,;29.02,-37.28,;30.21,-38.26,;31.66,-37.73,;27.59,-37.81,;26.4,-36.82,;26.14,-38.34,;27.32,-39.33,;34.66,-33.35,;33.89,-32.01,;34.67,-30.68,;33.9,-29.34,;36.21,-30.69,;36.97,-32.03,;38.51,-32.04,;36.2,-33.36,;34.58,-39.39,;34.56,-40.94,;35.88,-41.72,;37.23,-40.97,;37.25,-39.43,;35.92,-38.65,;38.55,-41.76,;38.53,-43.3,;39.89,-41.01,;41.22,-41.79,;42.56,-41.04,;43.95,-41.68,;45,-40.54,;44.24,-39.2,;42.73,-39.51,)| Show InChI InChI=1S/C33H41Cl2N7O2/c1-20(2)6-11-27(21-7-9-22(10-8-21)30(43)36-19-28-38-40-41-39-28)42-31(44)29(23-16-25(34)18-26(35)17-23)37-33(42)14-12-24(13-15-33)32(3,4)5/h7-10,16-18,20,24,27H,6,11-15,19H2,1-5H3,(H,36,43)(H,38,39,40,41)/t24-,27-,33-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [125I]-glucagon from GCGR in mouse liver membranes after 60 mins by scintillation counting analysis |
J Med Chem 57: 2601-10 (2014)
Article DOI: 10.1021/jm401858f
BindingDB Entry DOI: 10.7270/Q20V8F9P |
More data for this
Ligand-Target Pair | |
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