BDBM50007254 CHEMBL103139::Sodium; 6-[2-(4-fluoro-phenyl)-4-methyl-quinolin-3-yloxy]-3,5-dihydroxy-hexanoate

SMILES: Cc1c(OCC(O)C[C@@H](O)CC([O-])=O)c(nc2ccccc12)-c1ccc(F)cc1

InChI Key: InChIKey=CCRSFINJHYPQQP-TZHYSIJRSA-M

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50007254   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
HMG-CoA reductase (Rattus norvegicus (rat))	BDBM50007254 (CHEMBL103139 | Sodium; 6-[2-(4-fluoro-phenyl)-4-me...) Show SMILES Cc1c(OCC(O)C[C@@H](O)CC([O-])=O)c(nc2ccccc12)-c1ccc(F)cc1 Show InChI InChI=1S/C22H22FNO5/c1-13-18-4-2-3-5-19(18)24-21(14-6-8-15(23)9-7-14)22(13)29-12-17(26)10-16(25)11-20(27)28/h2-9,16-17,25-26H,10-12H2,1H3,(H,27,28)/p-1/t16-,17?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst AG Curated by ChEMBL					Assay Description In vitro inhibition of HMG-CoA reductase in solubilized rat liver.				J Med Chem 34: 2962-83 (1991) BindingDB Entry DOI: 10.7270/Q2C829WX
					More data for this Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) (Homo sapiens (Human))	BDBM50007254 (CHEMBL103139 | Sodium; 6-[2-(4-fluoro-phenyl)-4-me...) Show SMILES Cc1c(OCC(O)C[C@@H](O)CC([O-])=O)c(nc2ccccc12)-c1ccc(F)cc1 Show InChI InChI=1S/C22H22FNO5/c1-13-18-4-2-3-5-19(18)24-21(14-6-8-15(23)9-7-14)22(13)29-12-17(26)10-16(25)11-20(27)28/h2-9,16-17,25-26H,10-12H2,1H3,(H,27,28)/p-1/t16-,17?/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst AG Curated by ChEMBL					Assay Description Inhibition of the incorporation of sodium [14C]acetate into cholesterol in HEP G2 cells.				J Med Chem 34: 2962-83 (1991) BindingDB Entry DOI: 10.7270/Q2C829WX
					More data for this Ligand-Target Pair