BDBM50007499 8-{3-[4-(1,1-Dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-piperazin-1-yl]-propoxy}-8-aza-spiro[4.5]decane-7,9-dione::CHEMBL10658

SMILES: O=C1CC2(CCCC2)CC(=O)N1OCCCN1CCN(CC1)C1=NS(=O)(=O)c2ccccc12

InChI Key: InChIKey=NZLUWSOLFYRHOA-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50007499   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50007499 (8-{3-[4-(1,1-Dioxo-1H-1lambda*6*-benzo[d]isothiazo...) Show SMILES O=C1CC2(CCCC2)CC(=O)N1OCCCN1CCN(CC1)C1=NS(=O)(=O)c2ccccc12 |t:25| Show InChI InChI=1S/C23H30N4O5S/c28-20-16-23(8-3-4-9-23)17-21(29)27(20)32-15-5-10-25-11-13-26(14-12-25)22-18-6-1-2-7-19(18)33(30,31)24-22/h1-2,6-7H,3-5,8-17H2	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst-Roussel Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue				J Med Chem 34: 1068-72 (1991) BindingDB Entry DOI: 10.7270/Q2D21Z6P
					More data for this Ligand-Target Pair
Serotonin 2 (5-HT2) receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)	BDBM50007499 (8-{3-[4-(1,1-Dioxo-1H-1lambda*6*-benzo[d]isothiazo...) Show SMILES O=C1CC2(CCCC2)CC(=O)N1OCCCN1CCN(CC1)C1=NS(=O)(=O)c2ccccc12 |t:25| Show InChI InChI=1S/C23H30N4O5S/c28-20-16-23(8-3-4-9-23)17-21(29)27(20)32-15-5-10-25-11-13-26(14-12-25)22-18-6-1-2-7-19(18)33(30,31)24-22/h1-2,6-7H,3-5,8-17H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst-Roussel Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Compound was measured for affinity at 5-hydroxytryptamine 2 receptor in rat cortical by [3H]spiroperidol displacement.				J Med Chem 34: 1068-72 (1991) BindingDB Entry DOI: 10.7270/Q2D21Z6P
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50007499 (8-{3-[4-(1,1-Dioxo-1H-1lambda*6*-benzo[d]isothiazo...) Show SMILES O=C1CC2(CCCC2)CC(=O)N1OCCCN1CCN(CC1)C1=NS(=O)(=O)c2ccccc12 |t:25| Show InChI InChI=1S/C23H30N4O5S/c28-20-16-23(8-3-4-9-23)17-21(29)27(20)32-15-5-10-25-11-13-26(14-12-25)22-18-6-1-2-7-19(18)33(30,31)24-22/h1-2,6-7H,3-5,8-17H2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst-Roussel Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue				J Med Chem 34: 1068-72 (1991) BindingDB Entry DOI: 10.7270/Q2D21Z6P
					More data for this Ligand-Target Pair