BDBM50009174 CHEMBL3238365

SMILES: Cn1c(CN2C(=O)CN(C2=O)c2ccc(cc2)S(N)(=O)=O)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N

InChI Key: InChIKey=JPGRZQSDJVIPBG-INIZCTEOSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50009174   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasminogen (Homo sapiens (Human))	BDBM50009174 (CHEMBL3238365) Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(cc2)S(N)(=O)=O)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N |r| Show InChI InChI=1S/C24H27N9O5S/c1-31-18(10-15-12-28-21(30-22(15)31)23(35)29-16(11-26)4-2-3-9-25)13-33-20(34)14-32(24(33)36)17-5-7-19(8-6-17)39(27,37)38/h5-8,10,12,16H,2-4,9,13-14,25H2,1H3,(H,29,35)(H2,27,37,38)/t16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.60E+5	n/a	n/a	n/a	n/a	n/a	n/a
Hiroshima International University Curated by ChEMBL					Assay Description Inhibition of human plasmin using H-D-Val-Leu-LyspNA (S-2251) peptide as substrate assessed as reduction of enzyme hydrolytic activity				Bioorg Med Chem 22: 2339-52 (2014) Article DOI: 10.1016/j.bmc.2014.02.002 BindingDB Entry DOI: 10.7270/Q2KH0PVJ
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50009174 (CHEMBL3238365) Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(cc2)S(N)(=O)=O)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N |r| Show InChI InChI=1S/C24H27N9O5S/c1-31-18(10-15-12-28-21(30-22(15)31)23(35)29-16(11-26)4-2-3-9-25)13-33-20(34)14-32(24(33)36)17-5-7-19(8-6-17)39(27,37)38/h5-8,10,12,16H,2-4,9,13-14,25H2,1H3,(H,29,35)(H2,27,37,38)/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Hiroshima International University Curated by ChEMBL					Assay Description Inhibition of human plasma urokinase using Glu-Gly-Arg-pNA (S-2444) peptide as substrate assessed as reduction of enzyme hydrolytic activity				Bioorg Med Chem 22: 2339-52 (2014) Article DOI: 10.1016/j.bmc.2014.02.002 BindingDB Entry DOI: 10.7270/Q2KH0PVJ
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM50009174 (CHEMBL3238365) Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(cc2)S(N)(=O)=O)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N |r| Show InChI InChI=1S/C24H27N9O5S/c1-31-18(10-15-12-28-21(30-22(15)31)23(35)29-16(11-26)4-2-3-9-25)13-33-20(34)14-32(24(33)36)17-5-7-19(8-6-17)39(27,37)38/h5-8,10,12,16H,2-4,9,13-14,25H2,1H3,(H,29,35)(H2,27,37,38)/t16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Hiroshima International University Curated by ChEMBL					Assay Description Inhibition of human plasma kallikerin using H-D-Phe-Pro-Arg-pNA (S-2302) peptide as substrate assessed as reduction of enzyme hydrolytic activity				Bioorg Med Chem 22: 2339-52 (2014) Article DOI: 10.1016/j.bmc.2014.02.002 BindingDB Entry DOI: 10.7270/Q2KH0PVJ
					More data for this Ligand-Target Pair