BDBM50009205 CHEMBL3238379

SMILES: Cn1c(CN2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)c(c2)C(N)=O)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N

InChI Key: InChIKey=ZLMROGSLYUZRSG-FQEVSTJZSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50009205   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasminogen (Homo sapiens (Human))	BDBM50009205 (CHEMBL3238379) Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)c(c2)C(N)=O)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N |r| Show InChI InChI=1S/C31H31N9O5/c1-38-22(13-19-16-35-28(37-29(19)38)30(43)36-20(15-33)7-5-6-12-32)17-40-26(41)18-39(31(40)44)21-10-11-25(24(14-21)27(34)42)45-23-8-3-2-4-9-23/h2-4,8-11,13-14,16,20H,5-7,12,17-18,32H2,1H3,(H2,34,42)(H,36,43)/t20-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.10E+5	n/a	n/a	n/a	n/a	n/a	n/a
Hiroshima International University Curated by ChEMBL					Assay Description Inhibition of human plasmin using H-D-Val-Leu-LyspNA (S-2251) peptide as substrate assessed as reduction of enzyme hydrolytic activity				Bioorg Med Chem 22: 2339-52 (2014) Article DOI: 10.1016/j.bmc.2014.02.002 BindingDB Entry DOI: 10.7270/Q2KH0PVJ
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50009205 (CHEMBL3238379) Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)c(c2)C(N)=O)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N |r| Show InChI InChI=1S/C31H31N9O5/c1-38-22(13-19-16-35-28(37-29(19)38)30(43)36-20(15-33)7-5-6-12-32)17-40-26(41)18-39(31(40)44)21-10-11-25(24(14-21)27(34)42)45-23-8-3-2-4-9-23/h2-4,8-11,13-14,16,20H,5-7,12,17-18,32H2,1H3,(H2,34,42)(H,36,43)/t20-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Hiroshima International University Curated by ChEMBL					Assay Description Inhibition of human plasma urokinase using Glu-Gly-Arg-pNA (S-2444) peptide as substrate assessed as reduction of enzyme hydrolytic activity				Bioorg Med Chem 22: 2339-52 (2014) Article DOI: 10.1016/j.bmc.2014.02.002 BindingDB Entry DOI: 10.7270/Q2KH0PVJ
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM50009205 (CHEMBL3238379) Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)c(c2)C(N)=O)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N |r| Show InChI InChI=1S/C31H31N9O5/c1-38-22(13-19-16-35-28(37-29(19)38)30(43)36-20(15-33)7-5-6-12-32)17-40-26(41)18-39(31(40)44)21-10-11-25(24(14-21)27(34)42)45-23-8-3-2-4-9-23/h2-4,8-11,13-14,16,20H,5-7,12,17-18,32H2,1H3,(H2,34,42)(H,36,43)/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Hiroshima International University Curated by ChEMBL					Assay Description Inhibition of human plasma kallikerin using H-D-Phe-Pro-Arg-pNA (S-2302) peptide as substrate assessed as reduction of enzyme hydrolytic activity				Bioorg Med Chem 22: 2339-52 (2014) Article DOI: 10.1016/j.bmc.2014.02.002 BindingDB Entry DOI: 10.7270/Q2KH0PVJ
					More data for this Ligand-Target Pair