BDBM50011164 CHEMBL3259913

SMILES: COc1cc(cc(c1C(=O)NC1(CCCN(Cc2ccccc2)C1)c1ccccc1)C(F)(F)F)C(F)(F)F

InChI Key: InChIKey=MATNFYHKYBREMY-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50011164   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glycine transporter 1 (Homo sapiens (Human))	BDBM50011164 (CHEMBL3259913) Show SMILES COc1cc(cc(c1C(=O)NC1(CCCN(Cc2ccccc2)C1)c1ccccc1)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C28H26F6N2O2/c1-38-23-16-21(27(29,30)31)15-22(28(32,33)34)24(23)25(37)35-26(20-11-6-3-7-12-20)13-8-14-36(18-26)17-19-9-4-2-5-10-19/h2-7,9-12,15-16H,8,13-14,17-18H2,1H3,(H,35,37)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.70E+3	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Inhibition of human GlyT1 expressed in cells assessed as [3H]glycine uptake				ACS Med Chem Lett 5: 428-33 (2014) Article DOI: 10.1021/ml500005m BindingDB Entry DOI: 10.7270/Q2FF3TWV
					More data for this Ligand-Target Pair