BDBM50011182 CHEMBL3260318

SMILES: Cc1cc(C)nc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)ccc2C(N)=O)c1

InChI Key: InChIKey=FHLLUBJCTSMNCQ-DLBZAZTESA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50011182   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50011182 (CHEMBL3260318) Show SMILES Cc1cc(C)nc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)ccc2C(N)=O)c1 |r| Show InChI InChI=1S/C20H27N5O/c1-12-9-13(2)23-19(10-12)25-18-11-14(7-8-15(18)20(22)26)24-17-6-4-3-5-16(17)21/h7-11,16-17,24H,3-6,21H2,1-2H3,(H2,22,26)(H,23,25)/t16-,17+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co., Inc. Curated by ChEMBL					Assay Description Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...				J Med Chem 58: 1929-39 (2015) Article DOI: 10.1021/jm5018169 BindingDB Entry DOI: 10.7270/Q2028T7D
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50011182 (CHEMBL3260318) Show SMILES Cc1cc(C)nc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)ccc2C(N)=O)c1 |r| Show InChI InChI=1S/C20H27N5O/c1-12-9-13(2)23-19(10-12)25-18-11-14(7-8-15(18)20(22)26)24-17-6-4-3-5-16(17)21/h7-11,16-17,24H,3-6,21H2,1-2H3,(H2,22,26)(H,23,25)/t16-,17+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Dart Neuroscience LLC Curated by ChEMBL					Assay Description Inhibition of human recombinant SYK by HTRF assay				ACS Med Chem Lett 5: 278-9 (2014) Article DOI: 10.1021/ml500047f BindingDB Entry DOI: 10.7270/Q2251KQS
					More data for this Ligand-Target Pair