BindingDB PrimarySearch

BDBM50011421 2-(4-Nitro-phenyl)-chromen-4-one::CHEMBL64780

SMILES: [O-][N+](=O)c1ccc(cc1)-c1cc(=O)c2ccccc2o1

InChI Key: InChIKey=CKSVYVHLZNMXLX-UHFFFAOYSA-N

Data: 2 KI 6 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50011421
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Amine oxidase [flavin-containing] B (Homo sapiens (Human))	BDBM50011421 (2-(4-Nitro-phenyl)-chromen-4-one \| CHEMBL64780) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Birla Institute of Technology					Assay Description The activities of recombinant hMAO-A and hMAO-B were determined using p-tyramine as common substrate and calculated as 0.18 +/- 0.01 nmol/mg/min (n =...				Bioorg Chem 58: 72-80 (2015) Article DOI: 10.1016/j.bioorg.2014.11.008 BindingDB Entry DOI: 10.7270/Q2PG1QFJ
Birla Institute of Technology					More data for this Ligand-Target Pair
Amine oxidase (flavin-containing) A (Homo sapiens (Human))	BDBM50011421 (2-(4-Nitro-phenyl)-chromen-4-one \| CHEMBL64780) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	840	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Birla Institute of Technology					Assay Description The activities of recombinant hMAO-A and hMAO-B were determined using p-tyramine as common substrate and calculated as 0.18 +/- 0.01 nmol/mg/min (n =...				Bioorg Chem 58: 72-80 (2015) Article DOI: 10.1016/j.bioorg.2014.11.008 BindingDB Entry DOI: 10.7270/Q2PG1QFJ
Birla Institute of Technology					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50011421 (2-(4-Nitro-phenyl)-chromen-4-one \| CHEMBL64780) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Oulu Curated by ChEMBL					Assay Description Inhibition of human full length ARTD1 using NAD+ as substrate by fluorescence assay				J Med Chem 56: 7880-9 (2013) Article DOI: 10.1021/jm401463y BindingDB Entry DOI: 10.7270/Q2474C9C
University of Oulu Curated by ChEMBL					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 2 (Homo sapiens (Human))	BDBM50011421 (2-(4-Nitro-phenyl)-chromen-4-one \| CHEMBL64780) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	8.32E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Oulu Curated by ChEMBL					Assay Description Inhibition of human full length ARTD2 using NAD+ as substrate by fluorescence assay				J Med Chem 56: 7880-9 (2013) Article DOI: 10.1021/jm401463y BindingDB Entry DOI: 10.7270/Q2474C9C
University of Oulu Curated by ChEMBL					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50011421 (2-(4-Nitro-phenyl)-chromen-4-one \| CHEMBL64780) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.69E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Oulu Curated by ChEMBL					Assay Description Inhibition of human full length ARTD1 using NAD+ as substrate by fluorescence assay				J Med Chem 56: 7880-9 (2013) Article DOI: 10.1021/jm401463y BindingDB Entry DOI: 10.7270/Q2474C9C
University of Oulu Curated by ChEMBL					More data for this Ligand-Target Pair
Neuraminidase (Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)	BDBM50011421 (2-(4-Nitro-phenyl)-chromen-4-one \| CHEMBL64780) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	1.32E+4	n/a	n/a	n/a	n/a	n/a	n/a
Prin. K.M. Kundnani College of Pharmacy Curated by ChEMBL					Assay Description Inhibition of Influenza A virus (H1N1) neuraminidase				Bioorg Med Chem 28: (2020)
Prin. K.M. Kundnani College of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50011421 (2-(4-Nitro-phenyl)-chromen-4-one \| CHEMBL64780) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	>2.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.				J Med Chem 34: 798-806 (1991) BindingDB Entry DOI: 10.7270/Q2CF9P3J
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 2 (Homo sapiens (Human))	BDBM50011421 (2-(4-Nitro-phenyl)-chromen-4-one \| CHEMBL64780) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	8.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Oulu Curated by ChEMBL					Assay Description Inhibition of human full length ARTD2 using NAD+ as substrate by fluorescence assay				J Med Chem 56: 7880-9 (2013) Article DOI: 10.1021/jm401463y BindingDB Entry DOI: 10.7270/Q2474C9C
University of Oulu Curated by ChEMBL					More data for this Ligand-Target Pair