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BDBM50011651 6,8-Dichloro-1-{3-[4-(2-chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-2-yl]-prop-2-ynyl}-3,4-dihydro-1H-quinolin-2-one::CHEMBL20343

SMILES: Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1C(=O)CCc2cc(Cl)cc(Cl)c12)c1ccccc1Cl

InChI Key: InChIKey=IJVVLMZJLHUEKT-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50011651   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011651
PNG
(6,8-Dichloro-1-{3-[4-(2-chloro-phenyl)-9-methyl-6H...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1C(=O)CCc2cc(Cl)cc(Cl)c12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C27H18Cl3N5OS/c1-15-32-33-23-14-31-25(19-6-2-3-7-21(19)29)20-13-18(37-27(20)35(15)23)5-4-10-34-24(36)9-8-16-11-17(28)12-22(30)26(16)34/h2-3,6-7,11-13H,8-10,14H2,1H3
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n/an/a 9n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay


J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair