null

SMILES: OC(=O)c1nc(-c2ccccc2)n(c1-c1ccc(F)c(Cl)c1)-c1cccc(Cl)c1F

InChI Key: InChIKey=FQIJHXGZFVSBLN-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50012588   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50012588 (CHEMBL3260813) Show SMILES OC(=O)c1nc(-c2ccccc2)n(c1-c1ccc(F)c(Cl)c1)-c1cccc(Cl)c1F |(7.47,-12.21,;6.8,-13.6,;5.26,-13.71,;7.66,-14.88,;9.2,-14.93,;9.63,-16.41,;11.07,-16.94,;11.33,-18.46,;12.78,-18.99,;13.96,-18,;13.69,-16.48,;12.25,-15.95,;8.35,-17.27,;7.14,-16.32,;5.6,-16.32,;4.83,-17.64,;3.29,-17.64,;2.52,-16.3,;.98,-16.29,;3.3,-14.97,;2.53,-13.63,;4.84,-14.98,;8.29,-18.81,;6.93,-19.53,;6.87,-21.06,;8.18,-21.88,;9.54,-21.16,;10.85,-21.97,;9.59,-19.62,;10.95,-18.89,)| Show InChI InChI=1S/C22H12Cl2F2N2O2/c23-14-7-4-8-17(18(14)26)28-20(13-9-10-16(25)15(24)11-13)19(22(29)30)27-21(28)12-5-2-1-3-6-12/h1-11H,(H,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of MDM2 (unknown origin) (2 to 188) assessed as inhibition of p53-MDM2 interaction by TR-FRET assay				Bioorg Med Chem Lett 24: 2110-4 (2014) Article DOI: 10.1016/j.bmcl.2014.03.039 BindingDB Entry DOI: 10.7270/Q2RJ4M1C
					More data for this Ligand-Target Pair