BDBM50013074 2-(4-Butyl-phenylamino)-1,9-dihydro-purin-6-one::2-(4-Butyl-phenylamino)-1,9-dihydro-purin-6-one(BuPG)::CHEMBL16193
SMILES: CCCCc1ccc(Nc2nc3nc[nH]c3c(=O)[nH]2)cc1
InChI Key: InChIKey=OPAPDEANGWQVRT-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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DNA polymerase (alpha/delta/epsilon) (Homo sapiens (Human)) | BDBM50013074 (2-(4-Butyl-phenylamino)-1,9-dihydro-purin-6-one | ...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 7.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its inhibitory activity against HeLa DNA polymerase alpha, Ki values were obtained in the absence of dGTP | J Med Chem 27: 175-81 (1984) BindingDB Entry DOI: 10.7270/Q2HH6KMT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase (alpha/delta/epsilon) (Homo sapiens (Human)) | BDBM50013074 (2-(4-Butyl-phenylamino)-1,9-dihydro-purin-6-one | ...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for the concentration which gives half-maximal inhibition of Chinese Hamster Ovary DNA polymerase alpha | J Med Chem 30: 109-16 (1987) BindingDB Entry DOI: 10.7270/Q2ZG6R83 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thymidine kinase (Human herpesvirus 1 (strain SC16) (HHV-1) (Human h...) | BDBM50013074 (2-(4-Butyl-phenylamino)-1,9-dihydro-purin-6-one | ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a |
Istituto di Genetica Biochimica ed Evoluzionistica Curated by ChEMBL | Assay Description Inhibition of [3H]-MCC binding to torpedo electroplax membranes | J Med Chem 31: 1496-500 (1988) BindingDB Entry DOI: 10.7270/Q2930TR7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thymidine kinase (Human herpesvirus 2) | BDBM50013074 (2-(4-Butyl-phenylamino)-1,9-dihydro-purin-6-one | ...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 5.01E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Massachusetts Medical School Curated by ChEMBL | Assay Description Inhibitory activity against HSV-2 thymidine kinase isolated from HeLa cells | J Med Chem 35: 2979-83 (1992) BindingDB Entry DOI: 10.7270/Q29G5Q2Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thymidine kinase (Human herpesvirus 1 (strain SC16) (HHV-1) (Human h...) | BDBM50013074 (2-(4-Butyl-phenylamino)-1,9-dihydro-purin-6-one | ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Massachusetts Medical School Curated by ChEMBL | Assay Description Inhibition of TdR phosphorylation using thymidine kinase assay for herpes simplex virus type 1 | J Med Chem 33: 203-6 (1990) BindingDB Entry DOI: 10.7270/Q2B8573M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thymidine kinase (Human herpesvirus 1 (strain SC16) (HHV-1) (Human h...) | BDBM50013074 (2-(4-Butyl-phenylamino)-1,9-dihydro-purin-6-one | ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 5.01E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Massachusetts Medical School Curated by ChEMBL | Assay Description Inhibitory activity against HSV-1 thymidine kinase isolated from HeLa cells | J Med Chem 35: 2979-83 (1992) BindingDB Entry DOI: 10.7270/Q29G5Q2Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thymidine kinase (Human herpesvirus 1) | BDBM50013074 (2-(4-Butyl-phenylamino)-1,9-dihydro-purin-6-one | ...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Massachusetts Medical School Curated by ChEMBL | Assay Description Inhibition of TdR phosphorylation using thymidine kinase assay for herpes simplex virus type 1 | J Med Chem 33: 203-6 (1990) BindingDB Entry DOI: 10.7270/Q2B8573M | |||||||||||
More data for this Ligand-Target Pair |