BDBM50014546 CHEMBL3261410

SMILES: C[C@@H](CNc1cccc2n(ncc12)-c1ccccc1)NS(=O)(=O)c1c(C)cc(C)cc1C

InChI Key: InChIKey=AGWBORIZLLWBNO-FQEVSTJZSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50014546   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50014546 (CHEMBL3261410) Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1ccccc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C25H28N4O2S/c1-17-13-18(2)25(19(3)14-17)32(30,31)28-20(4)15-26-23-11-8-12-24-22(23)16-27-29(24)21-9-6-5-7-10-21/h5-14,16,20,26,28H,15H2,1-4H3/t20-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Agonist activity at glucocorticoid receptor in human Chago K1 cells assessed as gene transrepression by Lac-Z reporter gene assay				Bioorg Med Chem Lett 24: 2571-7 (2014) Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50014546 (CHEMBL3261410) Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1ccccc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C25H28N4O2S/c1-17-13-18(2)25(19(3)14-17)32(30,31)28-20(4)15-26-23-11-8-12-24-22(23)16-27-29(24)21-9-6-5-7-10-21/h5-14,16,20,26,28H,15H2,1-4H3/t20-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Binding affinity to human glucocorticoid receptor by fluorescence polarization assay				Bioorg Med Chem Lett 24: 2571-7 (2014) Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50014546 (CHEMBL3261410) Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1ccccc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C25H28N4O2S/c1-17-13-18(2)25(19(3)14-17)32(30,31)28-20(4)15-26-23-11-8-12-24-22(23)16-27-29(24)21-9-6-5-7-10-21/h5-14,16,20,26,28H,15H2,1-4H3/t20-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Agonist activity at glucocorticoid receptor in human PBMC assessed as inhibition of LPS-stimulated TNF-alpha release				Bioorg Med Chem Lett 24: 2571-7 (2014) Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6
					More data for this Ligand-Target Pair