null

SMILES: C1COCCN(C1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1

InChI Key: InChIKey=MUBBHSMQBJBMMG-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50015452   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50015452 (CHEMBL3265036) Show SMILES C1COCCN(C1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1 Show InChI InChI=1S/C24H23N7O/c1-9-30(11-13-32-12-1)20-6-4-19(5-7-20)27-23-24-25-8-10-31(24)16-22(28-23)17-2-3-18-15-26-29-21(18)14-17/h2-8,10,14-16H,1,9,11-13H2,(H,26,29)(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	73	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. Curated by ChEMBL					Assay Description Inhibition of Syk in antihuman IgM-stimulated human Ramos cells assessed as decrease in BCR-mediated BLNK phosphorylation by cellular assay				J Med Chem 57: 3856-73 (2014) Article DOI: 10.1021/jm500228a BindingDB Entry DOI: 10.7270/Q2B27WV1
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50015452 (CHEMBL3265036) Show SMILES C1COCCN(C1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1 Show InChI InChI=1S/C24H23N7O/c1-9-30(11-13-32-12-1)20-6-4-19(5-7-20)27-23-24-25-8-10-31(24)16-22(28-23)17-2-3-18-15-26-29-21(18)14-17/h2-8,10,14-16H,1,9,11-13H2,(H,26,29)(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. Curated by ChEMBL					Assay Description Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate				J Med Chem 57: 3856-73 (2014) Article DOI: 10.1021/jm500228a BindingDB Entry DOI: 10.7270/Q2B27WV1
					More data for this Ligand-Target Pair