BDBM50017244 (R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)propionic acid::2-Amino-3-(4-bromo-3-hydroxy-isoxazol-5-yl)-propionic acid::CHEMBL73698

SMILES: NC(Cc1o[nH]c(=O)c1Br)C(O)=O

InChI Key: InChIKey=JRTOQOAGTSUNHA-UHFFFAOYSA-N

Data: 8 KI  2 IC50  9 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50017244   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
GRIA1 (Homo sapiens (Human))	BDBM50017244 ((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...) Show SMILES NC(Cc1o[nH]c(=O)c1Br)C(O)=O Show InChI InChI=1S/C6H7BrN2O4/c7-4-3(13-9-5(4)10)1-2(8)6(11)12/h2H,1,8H2,(H,9,10)(H,11,12)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	170	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description Binding affinity of compound was determined towards cloned Ionotropic glutamate receptor AMPA 1 (GluR1) expressed in Sf 9 insect cells				J Med Chem 46: 2246-9 (2003) Article DOI: 10.1021/jm020588f BindingDB Entry DOI: 10.7270/Q26T0M06
					More data for this Ligand-Target Pair
GRIA2 (Homo sapiens (Human))	BDBM50017244 ((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...) Show SMILES NC(Cc1o[nH]c(=O)c1Br)C(O)=O Show InChI InChI=1S/C6H7BrN2O4/c7-4-3(13-9-5(4)10)1-2(8)6(11)12/h2H,1,8H2,(H,9,10)(H,11,12)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	250	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description Binding affinity of compound was determined towards cloned Ionotropic glutamate receptor AMPA 2 (GluR2) expressed in Sf 9 insect cells				J Med Chem 46: 2246-9 (2003) Article DOI: 10.1021/jm020588f BindingDB Entry DOI: 10.7270/Q26T0M06
					More data for this Ligand-Target Pair
GRIK1 (Homo sapiens (Human))	BDBM50017244 ((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...) Show SMILES NC(Cc1o[nH]c(=O)c1Br)C(O)=O Show InChI InChI=1S/C6H7BrN2O4/c7-4-3(13-9-5(4)10)1-2(8)6(11)12/h2H,1,8H2,(H,9,10)(H,11,12)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description Binding affinity of compound was determined towards cloned Ionotropic glutamate receptor ionotropic kainate 1 (GluR5) expressed in Sf 9 insect cells				J Med Chem 46: 2246-9 (2003) Article DOI: 10.1021/jm020588f BindingDB Entry DOI: 10.7270/Q26T0M06
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic AMPA (Homo sapiens (Human))	BDBM50017244 ((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...) Show SMILES NC(Cc1o[nH]c(=O)c1Br)C(O)=O Show InChI InChI=1S/C6H7BrN2O4/c7-4-3(13-9-5(4)10)1-2(8)6(11)12/h2H,1,8H2,(H,9,10)(H,11,12)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.17E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description Binding affinity of compound was determined towards cloned Ionotropic glutamate receptor AMPA 4 (GluR4) expressed in Sf 9 insect cells				J Med Chem 46: 2246-9 (2003) Article DOI: 10.1021/jm020588f BindingDB Entry DOI: 10.7270/Q26T0M06
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic AMPA (Homo sapiens (Human))	BDBM50017244 ((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...) Show SMILES NC(Cc1o[nH]c(=O)c1Br)C(O)=O Show InChI InChI=1S/C6H7BrN2O4/c7-4-3(13-9-5(4)10)1-2(8)6(11)12/h2H,1,8H2,(H,9,10)(H,11,12)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description Binding affinity of compound was determined towards cloned Ionotropic glutamate receptor AMPA 3 (GluR3) expressed in Sf 9 insect cells				J Med Chem 46: 2246-9 (2003) Article DOI: 10.1021/jm020588f BindingDB Entry DOI: 10.7270/Q26T0M06
					More data for this Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C) (Rattus norvegicus (Rat))	BDBM50017244 ((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...) Show SMILES NC(Cc1o[nH]c(=O)c1Br)C(O)=O Show InChI InChI=1S/C6H7BrN2O4/c7-4-3(13-9-5(4)10)1-2(8)6(11)12/h2H,1,8H2,(H,9,10)(H,11,12)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	3.40E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description Binding affinity of compound was determined against N-methyl-D-aspartate glutamate receptor, using radioligand [3H]- CGP-39653				J Med Chem 46: 2246-9 (2003) Article DOI: 10.1021/jm020588f BindingDB Entry DOI: 10.7270/Q26T0M06
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2 (Homo sapiens (Human))	BDBM50017244 ((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...) Show SMILES NC(Cc1o[nH]c(=O)c1Br)C(O)=O Show InChI InChI=1S/C6H7BrN2O4/c7-4-3(13-9-5(4)10)1-2(8)6(11)12/h2H,1,8H2,(H,9,10)(H,11,12)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description Binding affinity of compound was determined towards cloned Ionotropic glutamate receptor ionotropic kainate 6 (GluR6) expressed in Sf 9 insect cells				J Med Chem 46: 2246-9 (2003) Article DOI: 10.1021/jm020588f BindingDB Entry DOI: 10.7270/Q26T0M06
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50017244 ((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...) Show SMILES NC(Cc1o[nH]c(=O)c1Br)C(O)=O Show InChI InChI=1S/C6H7BrN2O4/c7-4-3(13-9-5(4)10)1-2(8)6(11)12/h2H,1,8H2,(H,9,10)(H,11,12)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	3.29E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description Antagonist activity of compound at Metabotropic glutamate receptor 1 was determined				J Med Chem 46: 2246-9 (2003) Article DOI: 10.1021/jm020588f BindingDB Entry DOI: 10.7270/Q26T0M06
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic AMPA (Homo sapiens (Human))	BDBM50017244 ((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...) Show SMILES NC(Cc1o[nH]c(=O)c1Br)C(O)=O Show InChI InChI=1S/C6H7BrN2O4/c7-4-3(13-9-5(4)10)1-2(8)6(11)12/h2H,1,8H2,(H,9,10)(H,11,12)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.02E+5	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Agonist activity at recombinant GluA3 receptor flop isoform expressed in Xenopus oocytes				Bioorg Med Chem 18: 1381-7 (2010) Article DOI: 10.1016/j.bmc.2009.12.072 BindingDB Entry DOI: 10.7270/Q27W6CB2
					More data for this Ligand-Target Pair
GRIA1 (Homo sapiens (Human))	BDBM50017244 ((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...) Show SMILES NC(Cc1o[nH]c(=O)c1Br)C(O)=O Show InChI InChI=1S/C6H7BrN2O4/c7-4-3(13-9-5(4)10)1-2(8)6(11)12/h2H,1,8H2,(H,9,10)(H,11,12)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Agonist activity at recombinant GluA1 receptor expressed in Xenopus oocytes				Bioorg Med Chem 18: 1381-7 (2010) Article DOI: 10.1016/j.bmc.2009.12.072 BindingDB Entry DOI: 10.7270/Q27W6CB2
					More data for this Ligand-Target Pair
GRIA2 (Homo sapiens (Human))	BDBM50017244 ((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...) Show SMILES NC(Cc1o[nH]c(=O)c1Br)C(O)=O Show InChI InChI=1S/C6H7BrN2O4/c7-4-3(13-9-5(4)10)1-2(8)6(11)12/h2H,1,8H2,(H,9,10)(H,11,12)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Agonist activity at recombinant GluA2 receptor flop isoform expressed in Xenopus oocytes				Bioorg Med Chem 18: 1381-7 (2010) Article DOI: 10.1016/j.bmc.2009.12.072 BindingDB Entry DOI: 10.7270/Q27W6CB2
					More data for this Ligand-Target Pair
GRIA1 (Homo sapiens (Human))	BDBM50017244 ((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...) Show SMILES NC(Cc1o[nH]c(=O)c1Br)C(O)=O Show InChI InChI=1S/C6H7BrN2O4/c7-4-3(13-9-5(4)10)1-2(8)6(11)12/h2H,1,8H2,(H,9,10)(H,11,12)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Agonist activity at recombinant GluA1 receptor flop isoform expressed in Xenopus oocytes				Bioorg Med Chem 18: 1381-7 (2010) Article DOI: 10.1016/j.bmc.2009.12.072 BindingDB Entry DOI: 10.7270/Q27W6CB2
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, AMPA (Mus musculus)	BDBM50017244 ((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...) Show SMILES NC(Cc1o[nH]c(=O)c1Br)C(O)=O Show InChI InChI=1S/C6H7BrN2O4/c7-4-3(13-9-5(4)10)1-2(8)6(11)12/h2H,1,8H2,(H,9,10)(H,11,12)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description Effective concentration of compound was determined for electrophysiological properties on Metabotropic glutamate receptor 1 using rat cortical slice ...				J Med Chem 46: 2246-9 (2003) Article DOI: 10.1021/jm020588f BindingDB Entry DOI: 10.7270/Q26T0M06
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 2 (Rattus norvegicus)	BDBM50017244 ((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...) Show SMILES NC(Cc1o[nH]c(=O)c1Br)C(O)=O Show InChI InChI=1S/C6H7BrN2O4/c7-4-3(13-9-5(4)10)1-2(8)6(11)12/h2H,1,8H2,(H,9,10)(H,11,12)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 2 (GluR2) using rat cort...				J Med Chem 46: 2246-9 (2003) Article DOI: 10.1021/jm020588f BindingDB Entry DOI: 10.7270/Q26T0M06
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 4 (Rattus norvegicus)	BDBM50017244 ((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...) Show SMILES NC(Cc1o[nH]c(=O)c1Br)C(O)=O Show InChI InChI=1S/C6H7BrN2O4/c7-4-3(13-9-5(4)10)1-2(8)6(11)12/h2H,1,8H2,(H,9,10)(H,11,12)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	3.80E+4	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 4 (GluR4) using rat cort...				J Med Chem 46: 2246-9 (2003) Article DOI: 10.1021/jm020588f BindingDB Entry DOI: 10.7270/Q26T0M06
					More data for this Ligand-Target Pair
GRIA3 (RAT)	BDBM50017244 ((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...) Show SMILES NC(Cc1o[nH]c(=O)c1Br)C(O)=O Show InChI InChI=1S/C6H7BrN2O4/c7-4-3(13-9-5(4)10)1-2(8)6(11)12/h2H,1,8H2,(H,9,10)(H,11,12)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.00E+5	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 3 (GluR3) using rat cort...				J Med Chem 46: 2246-9 (2003) Article DOI: 10.1021/jm020588f BindingDB Entry DOI: 10.7270/Q26T0M06
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Rattus norvegicus (Rat))	BDBM50017244 ((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...) Show SMILES NC(Cc1o[nH]c(=O)c1Br)C(O)=O Show InChI InChI=1S/C6H7BrN2O4/c7-4-3(13-9-5(4)10)1-2(8)6(11)12/h2H,1,8H2,(H,9,10)(H,11,12)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	650	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description Binding affinity of compound was determined against Ionotropic glutamate receptor AMPA receptor, using radioligand [3H]- AMPA				J Med Chem 46: 2246-9 (2003) Article DOI: 10.1021/jm020588f BindingDB Entry DOI: 10.7270/Q26T0M06
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic AMPA (Homo sapiens (Human))	BDBM50017244 ((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...) Show SMILES NC(Cc1o[nH]c(=O)c1Br)C(O)=O Show InChI InChI=1S/C6H7BrN2O4/c7-4-3(13-9-5(4)10)1-2(8)6(11)12/h2H,1,8H2,(H,9,10)(H,11,12)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.02E+5	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Agonist activity at recombinant GluA3 receptor expressed in Xenopus oocytes				Bioorg Med Chem 18: 1381-7 (2010) Article DOI: 10.1016/j.bmc.2009.12.072 BindingDB Entry DOI: 10.7270/Q27W6CB2
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate (Rattus norvegicus)	BDBM50017244 ((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...) Show SMILES NC(Cc1o[nH]c(=O)c1Br)C(O)=O Show InChI InChI=1S/C6H7BrN2O4/c7-4-3(13-9-5(4)10)1-2(8)6(11)12/h2H,1,8H2,(H,9,10)(H,11,12)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description Binding affinity of compound was determined against KA receptor, using radioligand [3H]- KA				J Med Chem 46: 2246-9 (2003) Article DOI: 10.1021/jm020588f BindingDB Entry DOI: 10.7270/Q26T0M06
					More data for this Ligand-Target Pair