BDBM50017442 3,3-Dioxo-4-{4-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-butyl}-10-oxa-3lambda*6*-thia-4-aza-tricyclo[5.2.1.0*2,6*]decan-5-one; dihydrochloride::CHEMBL3215525::CHEMBL537906
SMILES: Cl.Cl.FC(F)(F)c1cccc(c1)N1CCN(CCCCN2C(=O)C3C4CCC(O4)C3S2(=O)=O)CC1
InChI Key: InChIKey=DESLCFYPPRPCGH-UHFFFAOYSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50017442 (3,3-Dioxo-4-{4-[4-(3-trifluoromethyl-phenyl)-piper...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Curated by ChEMBL | Assay Description In vitro ability to inhibit [3H]-8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor of rat hippocampus and value ranges from 15 - 31 | J Med Chem 32: 1024-33 (1989) BindingDB Entry DOI: 10.7270/Q21G0MVD | |||||||||||
More data for this Ligand-Target Pair |