BDBM50019315 CHEMBL3289420

SMILES: O=C(NCCN1CCCCC1)c1cccn2c1nc1cc3ccccc3cc1c2=O

InChI Key: InChIKey=TXTDKLMFBBYADC-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50019315   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA-directed RNA polymerase I subunit RPA1 (Homo sapiens (Human))	BDBM50019315 (CHEMBL3289420) Show SMILES O=C(NCCN1CCCCC1)c1cccn2c1nc1cc3ccccc3cc1c2=O Show InChI InChI=1S/C24H24N4O2/c29-23(25-10-14-27-11-4-1-5-12-27)19-9-6-13-28-22(19)26-21-16-18-8-3-2-7-17(18)15-20(21)24(28)30/h2-3,6-9,13,15-16H,1,4-5,10-12,14H2,(H,25,29)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Johns Hopkins University School of Medicine Curated by ChEMBL					Assay Description Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis				J Med Chem 57: 4950-61 (2014) Article DOI: 10.1021/jm5004842 BindingDB Entry DOI: 10.7270/Q2M0470M
					More data for this Ligand-Target Pair