BDBM50019316 CHEMBL3289421

SMILES: O=C(NCCN1CCCC1)c1cccn2c1nc1cc3ccccc3cc1c2=O

InChI Key: InChIKey=QTAFSEJFKCZGEE-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50019316   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA-directed RNA polymerase I subunit RPA1 (Homo sapiens (Human))	BDBM50019316 (CHEMBL3289421) Show SMILES O=C(NCCN1CCCC1)c1cccn2c1nc1cc3ccccc3cc1c2=O Show InChI InChI=1S/C23H22N4O2/c28-22(24-9-13-26-10-3-4-11-26)18-8-5-12-27-21(18)25-20-15-17-7-2-1-6-16(17)14-19(20)23(27)29/h1-2,5-8,12,14-15H,3-4,9-11,13H2,(H,24,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Johns Hopkins University School of Medicine Curated by ChEMBL					Assay Description Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis				J Med Chem 57: 4950-61 (2014) Article DOI: 10.1021/jm5004842 BindingDB Entry DOI: 10.7270/Q2M0470M
					More data for this Ligand-Target Pair