BDBM50019321 CHEMBL3289426

SMILES: O=C(NCCN1CCOCC1)c1cccn2c1nc1cc3ccccc3cc1c2=O

InChI Key: InChIKey=KXSCXXIFXNDHCZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50019321   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA-directed RNA polymerase I subunit RPA1 (Homo sapiens (Human))	BDBM50019321 (CHEMBL3289426) Show SMILES O=C(NCCN1CCOCC1)c1cccn2c1nc1cc3ccccc3cc1c2=O Show InChI InChI=1S/C23H22N4O3/c28-22(24-7-9-26-10-12-30-13-11-26)18-6-3-8-27-21(18)25-20-15-17-5-2-1-4-16(17)14-19(20)23(27)29/h1-6,8,14-15H,7,9-13H2,(H,24,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.25E+3	n/a	n/a	n/a	n/a	n/a	n/a
Johns Hopkins University School of Medicine Curated by ChEMBL					Assay Description Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis				J Med Chem 57: 4950-61 (2014) Article DOI: 10.1021/jm5004842 BindingDB Entry DOI: 10.7270/Q2M0470M
					More data for this Ligand-Target Pair