BDBM50019670 2-Hydroxy-11-oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylic acid (4-pyridin-3-yl-butyl)-amide::CHEMBL57480
SMILES: Oc1ccc2nc3ccc(cn3c(=O)c2c1)C(=O)NCCCCc1cccnc1
InChI Key: InChIKey=CHNLXTZIULFMKR-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Thromboxane A2 Synthase (P450 TxA2) (Homo sapiens (Human)) | BDBM50019670 (2-Hydroxy-11-oxo-11H-pyrido[2,1-b]quinazoline-8-ca...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of human platelet thromboxane synthase (TXA2) was determined in human platelets | J Med Chem 30: 185-93 (1987) BindingDB Entry DOI: 10.7270/Q2222VBH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet activating factor receptor (Homo sapiens (Human)) | BDBM50019670 (2-Hydroxy-11-oxo-11H-pyrido[2,1-b]quinazoline-8-ca...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc. Curated by ChEMBL | Assay Description Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]-PAF as radioligand | J Med Chem 31: 466-72 (1988) BindingDB Entry DOI: 10.7270/Q2KK99S6 | |||||||||||
More data for this Ligand-Target Pair |