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SMILES: Cc1cc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)no1

InChI Key: InChIKey=ZOAWLPYNVYSMPB-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50020234   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020234 (CHEMBL3288520 | US9914707, I-24) Show SMILES Cc1cc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)no1 Show InChI InChI=1S/C22H17N5O2/c1-12-10-19(27-29-12)24-22(28)17-6-2-4-13-11-14(8-9-15(13)17)16-5-3-7-18-20(16)21(23)26-25-18/h2-11H,1H3,(H3,23,25,26)(H,24,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020234 (CHEMBL3288520 | US9914707, I-24) Show SMILES Cc1cc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)no1 Show InChI InChI=1S/C22H17N5O2/c1-12-10-19(27-29-12)24-22(28)17-6-2-4-13-11-14(8-9-15(13)17)16-5-3-7-18-20(16)21(23)26-25-18/h2-11H,1H3,(H3,23,25,26)(H,24,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.70	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...				J Med Chem 51: 725-36 (2008) BindingDB Entry DOI: 10.7270/Q2DR2XS5
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020234 (CHEMBL3288520 | US9914707, I-24) Show SMILES Cc1cc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)no1 Show InChI InChI=1S/C22H17N5O2/c1-12-10-19(27-29-12)24-22(28)17-6-2-4-13-11-14(8-9-15(13)17)16-5-3-7-18-20(16)21(23)26-25-18/h2-11H,1H3,(H3,23,25,26)(H,24,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.70	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair