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SMILES: Cc1ccc(NC(=O)c2ccc3ccccc3c2)cc1C(=O)Nc1cnc(Nc2cccc(NC(=O)C=C)c2)nc1

InChI Key: InChIKey=ALTLKLAKLUIKNV-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50020524   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM50020524
PNG
(CHEMBL3290151)
Show SMILES Cc1ccc(NC(=O)c2ccc3ccccc3c2)cc1C(=O)Nc1cnc(Nc2cccc(NC(=O)C=C)c2)nc1
Show InChI InChI=1S/C32H26N6O3/c1-3-29(39)35-24-9-6-10-25(16-24)38-32-33-18-27(19-34-32)37-31(41)28-17-26(14-11-20(28)2)36-30(40)23-13-12-21-7-4-5-8-22(21)15-23/h3-19H,1H2,2H3,(H,35,39)(H,36,40)(H,37,41)(H,33,34,38)
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Article
PubMed
n/an/a 22n/an/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of Btk (unknown origin) after 1 hr by HTRF assay

J Med Chem 57: 5112-28 (2014)


Article DOI: 10.1021/jm4017762
BindingDB Entry DOI: 10.7270/Q2NK3GKX
More data for this
Ligand-Target Pair