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SMILES: COc1ccc(-c2nc(c(-c3ccc(Cl)cc3)n2C(=O)N2CCN(CCO)CC2)-c2ccc(Cl)cc2)c(OC(C)C)c1

InChI Key: InChIKey=ROSNPAITVFVLCS-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50020725   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM50020725
PNG
(CHEMBL3291439)
Show SMILES COc1ccc(-c2nc(c(-c3ccc(Cl)cc3)n2C(=O)N2CCN(CCO)CC2)-c2ccc(Cl)cc2)c(OC(C)C)c1
Show InChI InChI=1S/C32H34Cl2N4O4/c1-21(2)42-28-20-26(41-3)12-13-27(28)31-35-29(22-4-8-24(33)9-5-22)30(23-6-10-25(34)11-7-23)38(31)32(40)37-16-14-36(15-17-37)18-19-39/h4-13,20-21,39H,14-19H2,1-3H3
PDB
MMDB

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Article
PubMed
n/an/a 260n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged HDM2 (unknown origin) expressed in Escherichia coli BL21 cells assessed as p53 activation by measuring inhibition of His-p53...

Eur J Med Chem 82: 472-9 (2014)


Article DOI: 10.1016/j.ejmech.2014.05.082
BindingDB Entry DOI: 10.7270/Q2GT5PR8
More data for this
Ligand-Target Pair