BDBM50021251 CHEMBL3287903

SMILES: CCCc1nc2cccnc2n1-c1ccc(Nc2ccc(C)cn2)cc1

InChI Key: InChIKey=OXAKSJQLHLRYAW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50021251   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50021251 (CHEMBL3287903) Show SMILES CCCc1nc2cccnc2n1-c1ccc(Nc2ccc(C)cn2)cc1 Show InChI InChI=1S/C21H21N5/c1-3-5-20-25-18-6-4-13-22-21(18)26(20)17-10-8-16(9-11-17)24-19-12-7-15(2)14-23-19/h4,6-14H,3,5H2,1-2H3,(H,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.70	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assay				ACS Med Chem Lett 5: 700-5 (2014) Article DOI: 10.1021/ml5000993 BindingDB Entry DOI: 10.7270/Q2T43VPW
					More data for this Ligand-Target Pair