BDBM50022495 6,7,8,9-tetrahydro-2'H,5'H-spiro[benzo[7]annulene-5,4'-imidazolidine]-2',5'-dione::6,7,8,9-tetrahydrospiro[benzo[7]annulene-5,4'-imidazolidine]-2',5'-dione::CHEMBL39377::spiro[6,7,8,9-tetrahydro-5H-benzo[a]cycloheptene-5,4'-(tetrahydro-1'H-imidazole)]-2',5'-dione
SMILES: O=C1NC(=O)C2(CCCCc3ccccc23)N1
InChI Key: InChIKey=BCSYSQVTCKMBMK-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Aldose reductase (ALR2) (Bos taurus (Cattle)) | BDBM50022495 (6,7,8,9-tetrahydro-2'H,5'H-spiro[benzo[7]annulene-...) | PDB GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research Curated by ChEMBL | Assay Description In vitro inhibition of partially purified calf lens aldose reductase | J Med Chem 31: 230-43 (1988) BindingDB Entry DOI: 10.7270/Q27D2VQF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type I I alpha subunit (Rattus norvegicus) | BDBM50022495 (6,7,8,9-tetrahydro-2'H,5'H-spiro[benzo[7]annulene-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.51E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alabama at Birmingham Curated by ChEMBL | Assay Description In vitro inhibition of Voltage-gated sodium channel by the displacement of [3H]batrachotoxin A 20-alpha-benzoate in rat brain cerebral cortex synapto... | J Med Chem 42: 1537-45 (1999) Article DOI: 10.1021/jm980556l BindingDB Entry DOI: 10.7270/Q2RJ4N61 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type I I alpha subunit (Rattus norvegicus) | BDBM50022495 (6,7,8,9-tetrahydro-2'H,5'H-spiro[benzo[7]annulene-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.51E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alabama at Birmingham Curated by ChEMBL | Assay Description Inhibition of [3H]BTX-B binding to Neuronal voltage-dependent sodium channel of rat cerebral cortex synaptoneurosomes | J Med Chem 40: 602-7 (1997) Article DOI: 10.1021/jm960692v BindingDB Entry DOI: 10.7270/Q2J96931 | |||||||||||
More data for this Ligand-Target Pair |