BDBM50022770 CHEMBL3298283

SMILES: CC1(CN2CCc3nc(OCc4cccc(F)c4)ccc3C2=O)COC1

InChI Key: InChIKey=PHIQTSQTVGCYPF-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50022770   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50022770 (CHEMBL3298283) Show SMILES CC1(CN2CCc3nc(OCc4cccc(F)c4)ccc3C2=O)COC1 Show InChI InChI=1S/C20H21FN2O3/c1-20(12-25-13-20)11-23-8-7-17-16(19(23)24)5-6-18(22-17)26-10-14-3-2-4-15(21)9-14/h2-6,9H,7-8,10-13H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.46E+3	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at rat mGlu5 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliza...				J Med Chem 57: 5620-37 (2014) Article DOI: 10.1021/jm500259z BindingDB Entry DOI: 10.7270/Q2736SHB
					More data for this Ligand-Target Pair