BDBM50022797 CHEMBL3298464

SMILES: Fc1ccc(nc1)N1CCc2nc(COc3cccc(F)c3)ccc2C1=O

InChI Key: InChIKey=WSLOMUUZOMJLPV-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50022797   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50022797 (CHEMBL3298464) Show SMILES Fc1ccc(nc1)N1CCc2nc(COc3cccc(F)c3)ccc2C1=O Show InChI InChI=1S/C20H15F2N3O2/c21-13-2-1-3-16(10-13)27-12-15-5-6-17-18(24-15)8-9-25(20(17)26)19-7-4-14(22)11-23-19/h1-7,10-11H,8-9,12H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	589	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at rat mGlu5 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliza...				J Med Chem 57: 5620-37 (2014) Article DOI: 10.1021/jm500259z BindingDB Entry DOI: 10.7270/Q2736SHB
					More data for this Ligand-Target Pair