BDBM50023325 2-Isopropyl-11-oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylic acid (6-pyrimidin-5-yl-hexyl)-amide::CHEMBL141825

SMILES: CC(C)c1ccc2nc3ccc(cn3c(=O)c2c1)C(=O)NCCCCCCc1cncnc1

InChI Key: InChIKey=XMGWUMLCQPDZIO-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50023325   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet activating factor receptor (Homo sapiens (Human))	BDBM50023325 (2-Isopropyl-11-oxo-11H-pyrido[2,1-b]quinazoline-8-...) Show SMILES CC(C)c1ccc2nc3ccc(cn3c(=O)c2c1)C(=O)NCCCCCCc1cncnc1 Show InChI InChI=1S/C26H29N5O2/c1-18(2)20-8-10-23-22(13-20)26(33)31-16-21(9-11-24(31)30-23)25(32)29-12-6-4-3-5-7-19-14-27-17-28-15-19/h8-11,13-18H,3-7,12H2,1-2H3,(H,29,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. Curated by ChEMBL					Assay Description Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]-PAF as radioligand				J Med Chem 31: 466-72 (1988) BindingDB Entry DOI: 10.7270/Q2KK99S6
					More data for this Ligand-Target Pair