BDBM50023453 (7,8-Dichloro-1,2,3,4-tetrahydro-isoquinolin-3-yl)-methanol::CHEMBL342957

SMILES: OCC1Cc2ccc(Cl)c(Cl)c2CN1

InChI Key: InChIKey=BYNFMAOUMAKLOM-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50023453   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Adrenergic receptor alpha-2 (RAT-NEONATAL RAT-Rattus norvegicus (rat))	BDBM50023453 ((7,8-Dichloro-1,2,3,4-tetrahydro-isoquinolin-3-yl)...) Show SMILES OCC1Cc2ccc(Cl)c(Cl)c2CN1 Show InChI InChI=1S/C10H11Cl2NO/c11-9-2-1-6-3-7(5-14)13-4-8(6)10(9)12/h1-2,7,13-14H,3-5H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Inhibition of [3H]clonidine binding to the rat alpha-2-adrenoceptor				Bioorg Med Chem Lett 9: 481-6 (1999) BindingDB Entry DOI: 10.7270/Q26Q20F9
					More data for this Ligand-Target Pair
Phenylethanolamine N-methyltransferase (Bos taurus (bovine))	BDBM50023453 ((7,8-Dichloro-1,2,3,4-tetrahydro-isoquinolin-3-yl)...) Show SMILES OCC1Cc2ccc(Cl)c(Cl)c2CN1 Show InChI InChI=1S/C10H11Cl2NO/c11-9-2-1-6-3-7(5-14)13-4-8(6)10(9)12/h1-2,7,13-14H,3-5H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	380	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Inhibitory activity against bovine adrenal phenylethanolamine N-methyl-transferase (PNMT)				Bioorg Med Chem Lett 9: 481-6 (1999) BindingDB Entry DOI: 10.7270/Q26Q20F9
					More data for this Ligand-Target Pair
Phenylethanolamine N-methyltransferase (Bos taurus (bovine))	BDBM50023453 ((7,8-Dichloro-1,2,3,4-tetrahydro-isoquinolin-3-yl)...) Show SMILES OCC1Cc2ccc(Cl)c(Cl)c2CN1 Show InChI InChI=1S/C10H11Cl2NO/c11-9-2-1-6-3-7(5-14)13-4-8(6)10(9)12/h1-2,7,13-14H,3-5H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	380	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description In vitro inhibitory activity measured against bovine adrenal phenylethanolamine N-methyltransferase(PNMT)				J Med Chem 31: 824-30 (1988) BindingDB Entry DOI: 10.7270/Q22N518P
					More data for this Ligand-Target Pair