BDBM50023866 CHEMBL3325509

SMILES: OCCN1CCC(CC1)NC(=O)c1ccc(COc2ccc(cc2)C(F)(F)F)cc1

InChI Key: InChIKey=MFWLAOMDPMVTEZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50023866   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glycine transporter 2 (Homo sapiens (Human))	BDBM50023866 (CHEMBL3325509) Show SMILES OCCN1CCC(CC1)NC(=O)c1ccc(COc2ccc(cc2)C(F)(F)F)cc1 Show InChI InChI=1S/C22H25F3N2O3/c23-22(24,25)18-5-7-20(8-6-18)30-15-16-1-3-17(4-2-16)21(29)26-19-9-11-27(12-10-19)13-14-28/h1-8,19,28H,9-15H2,(H,26,29)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
Toray Industries, Inc. Curated by ChEMBL					Assay Description Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs				Bioorg Med Chem Lett 24: 4603-6 (2014) Article DOI: 10.1016/j.bmcl.2014.06.059 BindingDB Entry DOI: 10.7270/Q2K64KN1
					More data for this Ligand-Target Pair