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SMILES: CC(C)(C)OC(=O)N1CC[C@H]([C@H](COc2cc(F)c(cc2F)S(=O)(=O)Nc2ncns2)C1)c1ccc(Cl)cc1

InChI Key: InChIKey=PMYALALOZZAFQF-WMZOPIPTSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50024207   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM50024207
PNG
(CHEMBL3325535)
Show SMILES CC(C)(C)OC(=O)N1CC[C@H]([C@H](COc2cc(F)c(cc2F)S(=O)(=O)Nc2ncns2)C1)c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C25H27ClF2N4O5S2/c1-25(2,3)37-24(33)32-9-8-18(15-4-6-17(26)7-5-15)16(12-32)13-36-21-10-20(28)22(11-19(21)27)39(34,35)31-23-29-14-30-38-23/h4-7,10-11,14,16,18H,8-9,12-13H2,1-3H3,(H,29,30,31)/t16-,18-/m0/s1
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Similars
Article
PubMed
n/an/a 164n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Nav1.7 expressed in HEK cells assessed as reduction in sodium current at -60 mV holding potential by PatchXpress platform based w...

Bioorg Med Chem Lett 24: 4397-401 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.017
BindingDB Entry DOI: 10.7270/Q2FF3TX9
More data for this
Ligand-Target Pair