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SMILES: FC(F)CN1CC[C@H]([C@H](COc2cc(F)c(cc2F)S(=O)(=O)Nc2ncns2)C1)c1ccc(Cl)cc1

InChI Key: InChIKey=HDTAHBLPSGGZDY-HOCLYGCPSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50024230   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM50024230
PNG
(CHEMBL3325539)
Show SMILES FC(F)CN1CC[C@H]([C@H](COc2cc(F)c(cc2F)S(=O)(=O)Nc2ncns2)C1)c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C22H21ClF4N4O3S2/c23-15-3-1-13(2-4-15)16-5-6-31(10-21(26)27)9-14(16)11-34-19-7-18(25)20(8-17(19)24)36(32,33)30-22-28-12-29-35-22/h1-4,7-8,12,14,16,21H,5-6,9-11H2,(H,28,29,30)/t14-,16-/m0/s1
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Similars
Article
PubMed
n/an/a 38n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Nav1.7 expressed in HEK cells assessed as reduction in sodium current at -60 mV holding potential by PatchXpress platform based w...

Bioorg Med Chem Lett 24: 4397-401 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.017
BindingDB Entry DOI: 10.7270/Q2FF3TX9
More data for this
Ligand-Target Pair