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SMILES: Cc1cnc(NS(=O)(=O)c2cc(F)c(OC[C@@H]3CNCC[C@H]3c3ccc(Cl)cc3)cc2F)s1

InChI Key: InChIKey=OPEKIKRIMJMTHW-RDJZCZTQSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50024234   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM50024234
PNG
(CHEMBL3325543)
Show SMILES Cc1cnc(NS(=O)(=O)c2cc(F)c(OC[C@@H]3CNCC[C@H]3c3ccc(Cl)cc3)cc2F)s1 |r|
Show InChI InChI=1S/C22H22ClF2N3O3S2/c1-13-10-27-22(32-13)28-33(29,30)21-9-18(24)20(8-19(21)25)31-12-15-11-26-7-6-17(15)14-2-4-16(23)5-3-14/h2-5,8-10,15,17,26H,6-7,11-12H2,1H3,(H,27,28)/t15-,17-/m0/s1
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Article
PubMed
n/an/a 116n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Nav1.7 expressed in HEK cells assessed as reduction in sodium current at -60 mV holding potential by PatchXpress platform based w...

Bioorg Med Chem Lett 24: 4397-401 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.017
BindingDB Entry DOI: 10.7270/Q2FF3TX9
More data for this
Ligand-Target Pair