BDBM50024605 CHEMBL3330603::US9290463, E
SMILES: Cn1c(=O)cnn(CCCCN2CCN(CC2)c2ccccc2)c1=O
InChI Key: InChIKey=ZIUFXZSHAGEVLS-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-HT1A/ 5-HT2c (Homo sapiens (Human)) | BDBM50024605 (CHEMBL3330603 | US9290463, E) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 0.150 | -12.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
The Trustees of Columbia University in the City of New York US Patent | Assay Description Preparation of Membrane Fractions from CHO-h5-HT1A Cells. Membranes from CHO cells stably expressing the human 5-HT1A receptor at a density of 8 pmol... | US Patent US9290463 (2016) BindingDB Entry DOI: 10.7270/Q2MS3RK0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50024605 (CHEMBL3330603 | US9290463, E) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Stony Brook University Curated by ChEMBL | Assay Description Displacement of [3H]8-OH-DPAT from 5HT1AR (unknown origin) by competition binding assay | Bioorg Med Chem Lett 24: 4759-62 (2014) Article DOI: 10.1016/j.bmcl.2014.07.048 BindingDB Entry DOI: 10.7270/Q2NZ896M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50024605 (CHEMBL3330603 | US9290463, E) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a |
Stony Brook University Curated by ChEMBL | Assay Description Agonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometry | Bioorg Med Chem Lett 24: 4759-62 (2014) Article DOI: 10.1016/j.bmcl.2014.07.048 BindingDB Entry DOI: 10.7270/Q2NZ896M | |||||||||||
More data for this Ligand-Target Pair |