BindingDB PrimarySearch

BDBM50026777 2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol::2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol (methoxamine)::2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol(Methoxamine)::CHEMBL524::METHOXAMINE::Vasoxyl

SMILES: COc1ccc(OC)c(c1)C(O)C(C)N

InChI Key: InChIKey=WJAJPNHVVFWKKL-UHFFFAOYSA-N

Data: 15 KI 3 IC50 1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50026777
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat))	BDBM50026777 (2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol \| 2-A...) Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	PubMed	940	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by PDSP K_i Database									Mol Pharmacol 13: 454-73 (1977) BindingDB Entry DOI: 10.7270/Q2TT4PFZ
TBA Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Alpha adrenergic receptor 1A and 1B (Rattus norvegicus (rat))	BDBM50026777 (2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol \| 2-A...) Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N Show InChI	Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	PubMed	1.61E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duke University Curated by PDSP K_i Database									J Biol Chem 266: 6365-9 (1991) BindingDB Entry DOI: 10.7270/Q2X928SG
Duke University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Cerebral cortex alpha adrenergic receptor (CALF)	BDBM50026777 (2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol \| 2-A...) Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duke University Curated by PDSP K_i Database									J Biol Chem 266: 6365-9 (1991) BindingDB Entry DOI: 10.7270/Q2X928SG
Duke University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
adrenergic Alpha2 (RAT)	BDBM50026777 (2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol \| 2-A...) Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by PDSP K_i Database									J Pharmacol Exp Ther 241: 1092-8 (1987) BindingDB Entry DOI: 10.7270/Q2F18X7B
University of California Curated by PDSP K_i Database					More data for this Ligand-Target Pair
adrenergic Alpha1 (HAMSTER)	BDBM50026777 (2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol \| 2-A...) Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N Show InChI	GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duke University Curated by PDSP K_i Database									J Pharmacol Exp Ther 272: 134-42 (1995) BindingDB Entry DOI: 10.7270/Q2ZC81CG
Duke University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
ADRA1B (C.H.O.)	BDBM50026777 (2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol \| 2-A...) Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N Show InChI	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Children's Medical Research Center Curated by PDSP K_i Database									Eur J Pharmacol 268: 399-407 (1994) Article DOI: 10.1016/0922-4106(94)90065-5 BindingDB Entry DOI: 10.7270/Q26W98KS
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50026777 (2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol \| 2-A...) Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	DrugBank PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duke University Curated by PDSP K_i Database									J Pharmacol Exp Ther 272: 134-42 (1995) BindingDB Entry DOI: 10.7270/Q2ZC81CG
Duke University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50026777 (2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol \| 2-A...) Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	DrugBank PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duke University Curated by PDSP K_i Database									J Pharmacol Exp Ther 272: 134-42 (1995) BindingDB Entry DOI: 10.7270/Q2ZC81CG
Duke University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50026777 (2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol \| 2-A...) Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	DrugBank PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duke University Curated by PDSP K_i Database									J Pharmacol Exp Ther 272: 134-42 (1995) BindingDB Entry DOI: 10.7270/Q2ZC81CG
Duke University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat))	BDBM50026777 (2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol \| 2-A...) Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duke University Curated by PDSP K_i Database									J Pharmacol Exp Ther 272: 134-42 (1995) BindingDB Entry DOI: 10.7270/Q2ZC81CG
Duke University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
adrenergic Alpha1 (BOVINE)	BDBM50026777 (2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol \| 2-A...) Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duke University Curated by PDSP K_i Database									J Pharmacol Exp Ther 272: 134-42 (1995) BindingDB Entry DOI: 10.7270/Q2ZC81CG
Duke University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat))	BDBM50026777 (2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol \| 2-A...) Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duke University Curated by PDSP K_i Database									J Biol Chem 266: 6365-9 (1991) BindingDB Entry DOI: 10.7270/Q2X928SG
Duke University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50026777 (2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol \| 2-A...) Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Children's Medical Research Center, Tokyo Curated by PDSP K_i Database									Biochem Biophys Res Commun 195: 902-9 (1993) Article DOI: 10.1006/bbrc.1993.2130 BindingDB Entry DOI: 10.7270/Q2FQ9V30
					More data for this Ligand-Target Pair
adrenergic Alpha2 (RAT)	BDBM50026777 (2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol \| 2-A...) Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by PDSP K_i Database									J Pharmacol Exp Ther 241: 1092-8 (1987) BindingDB Entry DOI: 10.7270/Q2F18X7B
University of California Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat))	BDBM50026777 (2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol \| 2-A...) Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	PubMed	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by PDSP K_i Database									Mol Pharmacol 13: 454-73 (1977) BindingDB Entry DOI: 10.7270/Q2TT4PFZ
TBA Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50026777 (2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol \| 2-A...) Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	DrugBank PubMed	n/a	n/a	n/a	n/a	720	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Alpha-1 adrenergic receptor agonist activity in rabbit ear artery				J Med Chem 24: 1432-7 (1982) BindingDB Entry DOI: 10.7270/Q2XW4KB0
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Adrenergic receptor alpha-2 (RAT-NEONATAL RAT-Rattus norvegicus (rat))	BDBM50026777 (2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol \| 2-A...) Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description 50% inhibition of specific [3H]clonidine binding (0.4 nM) to Alpha-2 adrenergic receptors in rat isolated brain membranes				J Med Chem 27: 495-503 (1984) BindingDB Entry DOI: 10.7270/Q24B31WH
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50026777 (2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol \| 2-A...) Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.70E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity against alpha-1 adrenergic receptor is the ability to inhibit the specific [3H]prazosin binding (0.4 nM) to rat isolated brain membr...				J Med Chem 27: 495-503 (1984) BindingDB Entry DOI: 10.7270/Q24B31WH
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Bile salt export pump (Homo sapiens (Human))	BDBM50026777 (2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol \| 2-A...) Show SMILES COc1ccc(OC)c(c1)C(O)C(C)N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...				Drug Metab Dispos 40: 2332-41 (2012) Article DOI: 10.1124/dmd.112.047068 BindingDB Entry DOI: 10.7270/Q2ZP488M
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair