Found 6 hits for monomerid = 50028029 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Protein kinase C theta type
(Homo sapiens (Human)) | BDBM50028029
(CHEMBL3338841)Show SMILES C1CN(CCN1)c1nc(cc2ccccc12)-c1ccc2[nH]ncc2c1 Show InChI InChI=1S/C20H19N5/c1-2-4-17-14(3-1)12-19(23-20(17)25-9-7-21-8-10-25)15-5-6-18-16(11-15)13-22-24-18/h1-6,11-13,21H,7-10H2,(H,22,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Horsham Research Centre
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PKC-theta after 60 mins by 33P-ATP incorporation assay |
Bioorg Med Chem Lett 24: 4812-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.002 BindingDB Entry DOI: 10.7270/Q2MP54VV |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50028029
(CHEMBL3338841)Show SMILES C1CN(CCN1)c1nc(cc2ccccc12)-c1ccc2[nH]ncc2c1 Show InChI InChI=1S/C20H19N5/c1-2-4-17-14(3-1)12-19(23-20(17)25-9-7-21-8-10-25)15-5-6-18-16(11-15)13-22-24-18/h1-6,11-13,21H,7-10H2,(H,22,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 141 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Horsham Research Centre
Curated by ChEMBL
| Assay Description Inhibition of ROCK-1 (unknown origin) |
Bioorg Med Chem Lett 24: 4812-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.002 BindingDB Entry DOI: 10.7270/Q2MP54VV |
More data for this Ligand-Target Pair | |
Protein kinase C, eta
(Homo sapiens (Human)) | BDBM50028029
(CHEMBL3338841)Show SMILES C1CN(CCN1)c1nc(cc2ccccc12)-c1ccc2[nH]ncc2c1 Show InChI InChI=1S/C20H19N5/c1-2-4-17-14(3-1)12-19(23-20(17)25-9-7-21-8-10-25)15-5-6-18-16(11-15)13-22-24-18/h1-6,11-13,21H,7-10H2,(H,22,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Horsham Research Centre
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PKC-eta after 60 mins by 33P-ATP incorporation assay |
Bioorg Med Chem Lett 24: 4812-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.002 BindingDB Entry DOI: 10.7270/Q2MP54VV |
More data for this Ligand-Target Pair | |
Protein kinase N1
(Homo sapiens (Human)) | BDBM50028029
(CHEMBL3338841)Show SMILES C1CN(CCN1)c1nc(cc2ccccc12)-c1ccc2[nH]ncc2c1 Show InChI InChI=1S/C20H19N5/c1-2-4-17-14(3-1)12-19(23-20(17)25-9-7-21-8-10-25)15-5-6-18-16(11-15)13-22-24-18/h1-6,11-13,21H,7-10H2,(H,22,24) | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Horsham Research Centre
Curated by ChEMBL
| Assay Description Inhibition of PKN-1 (unknown origin) |
Bioorg Med Chem Lett 24: 4812-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.002 BindingDB Entry DOI: 10.7270/Q2MP54VV |
More data for this Ligand-Target Pair | |
Protein kinase N2
(Homo sapiens (Human)) | BDBM50028029
(CHEMBL3338841)Show SMILES C1CN(CCN1)c1nc(cc2ccccc12)-c1ccc2[nH]ncc2c1 Show InChI InChI=1S/C20H19N5/c1-2-4-17-14(3-1)12-19(23-20(17)25-9-7-21-8-10-25)15-5-6-18-16(11-15)13-22-24-18/h1-6,11-13,21H,7-10H2,(H,22,24) | PDB
NCI pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 920 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Horsham Research Centre
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PKN-2 using AKRRRLSSLRA as substrate after 40 mins by scintillation counting analysis |
Bioorg Med Chem Lett 24: 4812-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.002 BindingDB Entry DOI: 10.7270/Q2MP54VV |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50028029
(CHEMBL3338841)Show SMILES C1CN(CCN1)c1nc(cc2ccccc12)-c1ccc2[nH]ncc2c1 Show InChI InChI=1S/C20H19N5/c1-2-4-17-14(3-1)12-19(23-20(17)25-9-7-21-8-10-25)15-5-6-18-16(11-15)13-22-24-18/h1-6,11-13,21H,7-10H2,(H,22,24) | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Horsham Research Centre
Curated by ChEMBL
| Assay Description Inhibition of human recombinant ROCK-2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate after 40 mins by scintillation counting analysis |
Bioorg Med Chem Lett 24: 4812-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.002 BindingDB Entry DOI: 10.7270/Q2MP54VV |
More data for this Ligand-Target Pair | |