BDBM50028976 4-(2-Chloro-5H-dibenzo[a,d]cyclohepten-10-yl)-1-methyl-piperidine::CHEMBL7430
SMILES: CN1CCC(CC1)C1=Cc2cc(Cl)ccc2Cc2ccccc12
InChI Key: InChIKey=ZABVPBHKTKEJLW-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Serotonin receptor 2a and 2c (5HT2A and 5HT2C) (Rattus norvegicus (Rat)) | BDBM50028976 (4-(2-Chloro-5H-dibenzo[a,d]cyclohepten-10-yl)-1-me...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Curated by ChEMBL | Assay Description Affinity was evaluated as inhibition constant for serotonin 5-hydroxytryptamine 2C receptor | J Med Chem 37: 2686-96 (1994) BindingDB Entry DOI: 10.7270/Q28051NX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat)) | BDBM50028976 (4-(2-Chloro-5H-dibenzo[a,d]cyclohepten-10-yl)-1-me...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Curated by ChEMBL | Assay Description Affinity was evaluated as inhibition constant for serotonin 5-hydroxytryptamine 2A receptor | J Med Chem 37: 2686-96 (1994) BindingDB Entry DOI: 10.7270/Q28051NX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor (Rattus norvegicus-RAT) | BDBM50028976 (4-(2-Chloro-5H-dibenzo[a,d]cyclohepten-10-yl)-1-me...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Curated by ChEMBL | Assay Description Affinity of the compound was evaluated as inhibition constant for serotonin 5-hydroxytryptamine 3 receptor | J Med Chem 37: 2686-96 (1994) BindingDB Entry DOI: 10.7270/Q28051NX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50028976 (4-(2-Chloro-5H-dibenzo[a,d]cyclohepten-10-yl)-1-me...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 560 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Curated by ChEMBL | Assay Description Affinity was evaluated as inhibition constant for dopamine D-2 receptor | J Med Chem 37: 2686-96 (1994) BindingDB Entry DOI: 10.7270/Q28051NX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(4) dopamine receptor (Homo sapiens (Human)) | BDBM50028976 (4-(2-Chloro-5H-dibenzo[a,d]cyclohepten-10-yl)-1-me...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Curated by ChEMBL | Assay Description Affinity was evaluated as inhibition constant for dopamine D-4 receptor | J Med Chem 37: 2686-96 (1994) BindingDB Entry DOI: 10.7270/Q28051NX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dopamine receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...) | BDBM50028976 (4-(2-Chloro-5H-dibenzo[a,d]cyclohepten-10-yl)-1-me...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | 678 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Relative affinity for dopamine receptor by displacement of [3H]spiroperidol (2.2 nM) from (in vitro) dopamine binding sites in rat caudate nuclei | J Med Chem 24: 1021-6 (1981) BindingDB Entry DOI: 10.7270/Q2348NKF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor (RAT) | BDBM50028976 (4-(2-Chloro-5H-dibenzo[a,d]cyclohepten-10-yl)-1-me...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | 622 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Concentration required (in vitro) to displace 50% specific binding of [3H]clozapine to Muscarinic acetylcholine receptor in rat brain | J Med Chem 24: 1021-6 (1981) BindingDB Entry DOI: 10.7270/Q2348NKF | |||||||||||
More data for this Ligand-Target Pair |