Found 9 hits for monomerid = 50029658 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50029658
(CHEMBL3353406)Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(C#N)c(n1)-c1cn(C)c2ccccc12 Show InChI InChI=1S/C29H32N8O2/c1-7-27(38)32-22-14-23(26(39-6)15-25(22)36(4)13-12-35(2)3)33-29-31-17-19(16-30)28(34-29)21-18-37(5)24-11-9-8-10-20(21)24/h7-11,14-15,17-18H,1,12-13H2,2-6H3,(H,32,38)(H,31,33,34) | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of EGFR L858R/T970M double mutant phosphorylation in human NCI-H1975 cells after 2 hrs by fluorescence assay |
J Med Chem 57: 8249-67 (2014)
Article DOI: 10.1021/jm500973a BindingDB Entry DOI: 10.7270/Q2ZS2Z4C |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50029658
(CHEMBL3353406)Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(C#N)c(n1)-c1cn(C)c2ccccc12 Show InChI InChI=1S/C29H32N8O2/c1-7-27(38)32-22-14-23(26(39-6)15-25(22)36(4)13-12-35(2)3)33-29-31-17-19(16-30)28(34-29)21-18-37(5)24-11-9-8-10-20(21)24/h7-11,14-15,17-18H,1,12-13H2,2-6H3,(H,32,38)(H,31,33,34) | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of EGFR exon 19 deletion activating mutant phosphorylation in human PC9 cells after 2 hrs by fluorescence assay |
J Med Chem 57: 8249-67 (2014)
Article DOI: 10.1021/jm500973a BindingDB Entry DOI: 10.7270/Q2ZS2Z4C |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50029658
(CHEMBL3353406)Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(C#N)c(n1)-c1cn(C)c2ccccc12 Show InChI InChI=1S/C29H32N8O2/c1-7-27(38)32-22-14-23(26(39-6)15-25(22)36(4)13-12-35(2)3)33-29-31-17-19(16-30)28(34-29)21-18-37(5)24-11-9-8-10-20(21)24/h7-11,14-15,17-18H,1,12-13H2,2-6H3,(H,32,38)(H,31,33,34) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of wild type EGFR phosphorylation in human LoVo cells after 2 hrs by fluorescence assay |
J Med Chem 57: 8249-67 (2014)
Article DOI: 10.1021/jm500973a BindingDB Entry DOI: 10.7270/Q2ZS2Z4C |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50029658
(CHEMBL3353406)Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(C#N)c(n1)-c1cn(C)c2ccccc12 Show InChI InChI=1S/C29H32N8O2/c1-7-27(38)32-22-14-23(26(39-6)15-25(22)36(4)13-12-35(2)3)33-29-31-17-19(16-30)28(34-29)21-18-37(5)24-11-9-8-10-20(21)24/h7-11,14-15,17-18H,1,12-13H2,2-6H3,(H,32,38)(H,31,33,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human ERG |
J Med Chem 57: 8249-67 (2014)
Article DOI: 10.1021/jm500973a BindingDB Entry DOI: 10.7270/Q2ZS2Z4C |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50029658
(CHEMBL3353406)Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(C#N)c(n1)-c1cn(C)c2ccccc12 Show InChI InChI=1S/C29H32N8O2/c1-7-27(38)32-22-14-23(26(39-6)15-25(22)36(4)13-12-35(2)3)33-29-31-17-19(16-30)28(34-29)21-18-37(5)24-11-9-8-10-20(21)24/h7-11,14-15,17-18H,1,12-13H2,2-6H3,(H,32,38)(H,31,33,34) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangxi Science & Technology Normal University
Curated by ChEMBL
| Assay Description Inhibition of EGFR T790M/L858R double mutant (unknown origin) using substrate-biotin by ELISA-based mobility shift assay |
Eur J Med Chem 163: 367-380 (2019)
Article DOI: 10.1016/j.ejmech.2018.11.069 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50029658
(CHEMBL3353406)Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(C#N)c(n1)-c1cn(C)c2ccccc12 Show InChI InChI=1S/C29H32N8O2/c1-7-27(38)32-22-14-23(26(39-6)15-25(22)36(4)13-12-35(2)3)33-29-31-17-19(16-30)28(34-29)21-18-37(5)24-11-9-8-10-20(21)24/h7-11,14-15,17-18H,1,12-13H2,2-6H3,(H,32,38)(H,31,33,34) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 311 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangxi Science & Technology Normal University
Curated by ChEMBL
| Assay Description Inhibition of wild-type EGFR (unknown origin) using substrate-biotin by ELISA-based mobility shift assay |
Eur J Med Chem 163: 367-380 (2019)
Article DOI: 10.1016/j.ejmech.2018.11.069 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50029658
(CHEMBL3353406)Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(C#N)c(n1)-c1cn(C)c2ccccc12 Show InChI InChI=1S/C29H32N8O2/c1-7-27(38)32-22-14-23(26(39-6)15-25(22)36(4)13-12-35(2)3)33-29-31-17-19(16-30)28(34-29)21-18-37(5)24-11-9-8-10-20(21)24/h7-11,14-15,17-18H,1,12-13H2,2-6H3,(H,32,38)(H,31,33,34) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 311 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangxi Science & Technology Normal University
Curated by ChEMBL
| Assay Description Inhibition of wild-type EGFR (unknown origin) using substrate-biotin by ELISA-based mobility shift assay |
Eur J Med Chem 163: 367-380 (2019)
Article DOI: 10.1016/j.ejmech.2018.11.069 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50029658
(CHEMBL3353406)Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(C#N)c(n1)-c1cn(C)c2ccccc12 Show InChI InChI=1S/C29H32N8O2/c1-7-27(38)32-22-14-23(26(39-6)15-25(22)36(4)13-12-35(2)3)33-29-31-17-19(16-30)28(34-29)21-18-37(5)24-11-9-8-10-20(21)24/h7-11,14-15,17-18H,1,12-13H2,2-6H3,(H,32,38)(H,31,33,34) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangxi Science & Technology Normal University
Curated by ChEMBL
| Assay Description Inhibition of EGFR T790M/L858R double mutant (unknown origin) using substrate-biotin by ELISA-based mobility shift assay |
Eur J Med Chem 163: 367-380 (2019)
Article DOI: 10.1016/j.ejmech.2018.11.069 |
More data for this Ligand-Target Pair | |
Insulin-like growth factor I receptor
(Homo sapiens (Human)) | BDBM50029658
(CHEMBL3353406)Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(C#N)c(n1)-c1cn(C)c2ccccc12 Show InChI InChI=1S/C29H32N8O2/c1-7-27(38)32-22-14-23(26(39-6)15-25(22)36(4)13-12-35(2)3)33-29-31-17-19(16-30)28(34-29)21-18-37(5)24-11-9-8-10-20(21)24/h7-11,14-15,17-18H,1,12-13H2,2-6H3,(H,32,38)(H,31,33,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of IGF1R (unknown origin) |
J Med Chem 57: 8249-67 (2014)
Article DOI: 10.1021/jm500973a BindingDB Entry DOI: 10.7270/Q2ZS2Z4C |
More data for this Ligand-Target Pair | |