Found 3 hits for monomerid = 50032620 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50032620
(CHEMBL3354184)Show SMILES OC1CCN(CC1)c1nccc(Nc2cc(NC(=O)c3c(Cl)cccc3Cl)ccn2)n1 Show InChI InChI=1S/C21H20Cl2N6O2/c22-15-2-1-3-16(23)19(15)20(31)26-13-4-8-24-18(12-13)27-17-5-9-25-21(28-17)29-10-6-14(30)7-11-29/h1-5,8-9,12,14,30H,6-7,10-11H2,(H2,24,25,26,27,28,31) | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc.
Curated by ChEMBL
| Assay Description Inhibition of EGFR T790M/L858R mutant (unknown origin) by high-throughput biochemical screening |
J Med Chem 57: 10176-91 (2014)
Article DOI: 10.1021/jm501578n BindingDB Entry DOI: 10.7270/Q2XK8H5B |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50032620
(CHEMBL3354184)Show SMILES OC1CCN(CC1)c1nccc(Nc2cc(NC(=O)c3c(Cl)cccc3Cl)ccn2)n1 Show InChI InChI=1S/C21H20Cl2N6O2/c22-15-2-1-3-16(23)19(15)20(31)26-13-4-8-24-18(12-13)27-17-5-9-25-21(28-17)29-10-6-14(30)7-11-29/h1-5,8-9,12,14,30H,6-7,10-11H2,(H2,24,25,26,27,28,31) | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 76 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc.
Curated by ChEMBL
| Assay Description Inhibition of EGFR T790M/del746 to 750 mutant (unknown origin) by high-throughput biochemical screening |
J Med Chem 57: 10176-91 (2014)
Article DOI: 10.1021/jm501578n BindingDB Entry DOI: 10.7270/Q2XK8H5B |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50032620
(CHEMBL3354184)Show SMILES OC1CCN(CC1)c1nccc(Nc2cc(NC(=O)c3c(Cl)cccc3Cl)ccn2)n1 Show InChI InChI=1S/C21H20Cl2N6O2/c22-15-2-1-3-16(23)19(15)20(31)26-13-4-8-24-18(12-13)27-17-5-9-25-21(28-17)29-10-6-14(30)7-11-29/h1-5,8-9,12,14,30H,6-7,10-11H2,(H2,24,25,26,27,28,31) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 716 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc.
Curated by ChEMBL
| Assay Description Inhibition of wild-type EGFR (unknown origin) by high-throughput biochemical screening |
J Med Chem 57: 10176-91 (2014)
Article DOI: 10.1021/jm501578n BindingDB Entry DOI: 10.7270/Q2XK8H5B |
More data for this Ligand-Target Pair | |