Found 3 hits for monomerid = 50032634 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50032634
(CHEMBL3354193)Show SMILES COC1CCN(CC1)c1nccc(Nc2cc3n(C(C)C)c(=O)[nH]c3cn2)n1 Show InChI InChI=1S/C19H25N7O2/c1-12(2)26-15-10-17(21-11-14(15)22-19(26)27)23-16-4-7-20-18(24-16)25-8-5-13(28-3)6-9-25/h4,7,10-13H,5-6,8-9H2,1-3H3,(H,22,27)(H,20,21,23,24) | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 114 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc.
Curated by ChEMBL
| Assay Description Inhibition of EGFR T790M/L858R mutant (unknown origin) by high-throughput biochemical screening |
J Med Chem 57: 10176-91 (2014)
Article DOI: 10.1021/jm501578n BindingDB Entry DOI: 10.7270/Q2XK8H5B |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50032634
(CHEMBL3354193)Show SMILES COC1CCN(CC1)c1nccc(Nc2cc3n(C(C)C)c(=O)[nH]c3cn2)n1 Show InChI InChI=1S/C19H25N7O2/c1-12(2)26-15-10-17(21-11-14(15)22-19(26)27)23-16-4-7-20-18(24-16)25-8-5-13(28-3)6-9-25/h4,7,10-13H,5-6,8-9H2,1-3H3,(H,22,27)(H,20,21,23,24) | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 156 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc.
Curated by ChEMBL
| Assay Description Inhibition of EGFR T790M/del746 to 750 mutant (unknown origin) by high-throughput biochemical screening |
J Med Chem 57: 10176-91 (2014)
Article DOI: 10.1021/jm501578n BindingDB Entry DOI: 10.7270/Q2XK8H5B |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50032634
(CHEMBL3354193)Show SMILES COC1CCN(CC1)c1nccc(Nc2cc3n(C(C)C)c(=O)[nH]c3cn2)n1 Show InChI InChI=1S/C19H25N7O2/c1-12(2)26-15-10-17(21-11-14(15)22-19(26)27)23-16-4-7-20-18(24-16)25-8-5-13(28-3)6-9-25/h4,7,10-13H,5-6,8-9H2,1-3H3,(H,22,27)(H,20,21,23,24) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc.
Curated by ChEMBL
| Assay Description Inhibition of wild-type EGFR (unknown origin) by high-throughput biochemical screening |
J Med Chem 57: 10176-91 (2014)
Article DOI: 10.1021/jm501578n BindingDB Entry DOI: 10.7270/Q2XK8H5B |
More data for this Ligand-Target Pair | |