BDBM50033387 CHEMBL3357653

SMILES: CCOc1cc2ncnc(Nc3ccc(OCC4CC4)c(Cl)c3)c2cc1NC(=O)C(\F)=C/CN(C)C

InChI Key: InChIKey=CPKOOPNFOWNEFT-AWQFTUOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50033387   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50033387 (CHEMBL3357653) Show SMILES CCOc1cc2ncnc(Nc3ccc(OCC4CC4)c(Cl)c3)c2cc1NC(=O)C(\F)=C/CN(C)C Show InChI InChI=1S/C26H29ClFN5O3/c1-4-35-24-13-21-18(12-22(24)32-26(34)20(28)9-10-33(2)3)25(30-15-29-21)31-17-7-8-23(19(27)11-17)36-14-16-5-6-16/h7-9,11-13,15-16H,4-6,10,14H2,1-3H3,(H,32,34)(H,29,30,31)/b20-9+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Zhejiang University Curated by ChEMBL					Assay Description Inhibition of wild type EGFR (unknown origin) incubated for 5 mins by HTRF assay				J Med Chem 57: 9889-900 (2014) Article DOI: 10.1021/jm5014659 BindingDB Entry DOI: 10.7270/Q26W9CPC
					More data for this Ligand-Target Pair