BDBM50033983 1-{5-[4,5-Bis-(4-methoxy-phenyl)-1H-imidazol-2-ylsulfanyl]-pentyl}-3-(2,4-difluoro-phenyl)-1-(2-morpholin-4-yl-ethyl)-urea::CHEMBL269470

SMILES: COc1ccc(cc1)-c1nc(SCCCCCN(CCN2CCOCC2)C(=O)Nc2ccc(F)cc2F)[nH]c1-c1ccc(OC)cc1

InChI Key: InChIKey=LPADDMYZAKVZBR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50033983   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sterol O-acyltransferase, Soat (Rattus norvegicus)	BDBM50033983 (1-{5-[4,5-Bis-(4-methoxy-phenyl)-1H-imidazol-2-yls...) Show SMILES COc1ccc(cc1)-c1nc(SCCCCCN(CCN2CCOCC2)C(=O)Nc2ccc(F)cc2F)[nH]c1-c1ccc(OC)cc1 Show InChI InChI=1S/C35H41F2N5O4S/c1-44-28-11-6-25(7-12-28)32-33(26-8-13-29(45-2)14-9-26)40-34(39-32)47-23-5-3-4-16-42(18-17-41-19-21-46-22-20-41)35(43)38-31-15-10-27(36)24-30(31)37/h6-15,24H,3-5,16-23H2,1-2H3,(H,38,43)(H,39,40)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Merck Research Laboratories Curated by ChEMBL					Assay Description Concentration required to inhibit 50% activity of Acyl coenzyme A:cholesterol acyltransferase 1 in vitro using rat liver microsome.				J Med Chem 38: 1067-83 (1995) BindingDB Entry DOI: 10.7270/Q28S4P0T
					More data for this Ligand-Target Pair