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BDBM50033986 1-(2-{2-[4,5-Bis-(4-methoxy-phenyl)-1H-imidazol-2-ylsulfanyl]-ethoxy}-ethyl)-1-heptyl-3-isopropyl-urea::CHEMBL273510

SMILES: CCCCCCCN(CCOCCSc1nc(c([nH]1)-c1ccc(OC)cc1)-c1ccc(OC)cc1)C(=O)NC(C)C

InChI Key: InChIKey=NKFSTWIQTSFKLD-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50033986   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sterol O-acyltransferase, Soat


(Rattus norvegicus)		BDBM50033986
PNG
(1-(2-{2-[4,5-Bis-(4-methoxy-phenyl)-1H-imidazol-2-...)
Show SMILES CCCCCCCN(CCOCCSc1nc(c([nH]1)-c1ccc(OC)cc1)-c1ccc(OC)cc1)C(=O)NC(C)C
Show InChI InChI=1S/C32H46N4O4S/c1-6-7-8-9-10-19-36(32(37)33-24(2)3)20-21-40-22-23-41-31-34-29(25-11-15-27(38-4)16-12-25)30(35-31)26-13-17-28(39-5)18-14-26/h11-18,24H,6-10,19-23H2,1-5H3,(H,33,37)(H,34,35)
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PC sid
UniChem

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PubMed
n/an/a 850n/an/an/an/an/an/a



DuPont Merck Research Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit 50% activity of Acyl coenzyme A:cholesterol acyltransferase 1 in vitro using rat liver microsome.

J Med Chem 38: 1067-83 (1995)


BindingDB Entry DOI: 10.7270/Q28S4P0T
More data for this
Ligand-Target Pair