BDBM50034014 (S)-4-Ethyl-4-hydroxy-11-methyl-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,8,12a-triaza-dibenzo[b,h]fluorene-9-carbonitrile::4-Ethyl-4-hydroxy-11-methyl-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,8,12a-triaza-dibenzo[b,h]fluorene-9-carbonitrile::CHEMBL13998
SMILES: CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cnc(cc4c(C)c3Cn1c2=O)C#N
InChI Key: InChIKey=QBEZNPSUEOUWPW-NRFANRHFSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DNA topoisomerase I (Topo I) (Homo sapiens (Human)) | BDBM50034014 ((S)-4-Ethyl-4-hydroxy-11-methyl-3,13-dioxo-3,4,12,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 143 | n/a | n/a | n/a | n/a | n/a | n/a |
NeoGenesis, Inc. Curated by ChEMBL | Assay Description Inhibitory activity against DNA topoisomerase I | J Med Chem 43: 1993-2006 (2000) BindingDB Entry DOI: 10.7270/Q2MP53ZS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase I (Topo I) (Homo sapiens (Human)) | BDBM50034014 ((S)-4-Ethyl-4-hydroxy-11-methyl-3,13-dioxo-3,4,12,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 143 | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Inc. Curated by ChEMBL | Assay Description In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase. | J Med Chem 38: 1106-18 (1995) BindingDB Entry DOI: 10.7270/Q2X067P4 | |||||||||||
More data for this Ligand-Target Pair |