BDBM50034647 CHEMBL3360412
SMILES: COc1ccc(NC(=O)[C@@H](C)Nc2nc3n(ncc3c(=O)[nH]2)-c2ccccc2Cl)cc1
InChI Key: InChIKey=NGJKWXIPEUHCJA-GFCCVEGCSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphodiesterase 9A (Homo sapiens (Human)) | BDBM50034647 (CHEMBL3360412) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-Sen University Curated by ChEMBL | Assay Description Inhibition of PDE9A2 catalytic domain (unknown origin) using [3H]-cGMP/[3H]-cAMP as substrate after 15 mins by liquid scintillation counting analysis | J Med Chem 57: 10304-13 (2014) Article DOI: 10.1021/jm500836h BindingDB Entry DOI: 10.7270/Q28P624W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human)) | BDBM50034647 (CHEMBL3360412) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-Sen University Curated by ChEMBL | Assay Description Inhibition of PDE1B2 catalytic domain (unknown origin) using [3H]-cGMP/[3H]-cAMP as substrate after 15 mins by liquid scintillation counting analysis | J Med Chem 57: 10304-13 (2014) Article DOI: 10.1021/jm500836h BindingDB Entry DOI: 10.7270/Q28P624W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50034647 (CHEMBL3360412) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-Sen University Curated by ChEMBL | Assay Description Inhibition of PDE10A2 catalytic domain (unknown origin) using [3H]-cGMP/[3H]-cAMP as substrate after 15 mins by liquid scintillation counting analysi... | J Med Chem 57: 10304-13 (2014) Article DOI: 10.1021/jm500836h BindingDB Entry DOI: 10.7270/Q28P624W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 7 (Homo sapiens (Human)) | BDBM50034647 (CHEMBL3360412) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.12E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-Sen University Curated by ChEMBL | Assay Description Inhibition of PDE7A1 catalytic domain (unknown origin) using [3H]-cGMP/[3H]-cAMP as substrate after 15 mins by liquid scintillation counting analysis | J Med Chem 57: 10304-13 (2014) Article DOI: 10.1021/jm500836h BindingDB Entry DOI: 10.7270/Q28P624W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 8 (Homo sapiens (Human)) | BDBM50034647 (CHEMBL3360412) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-Sen University Curated by ChEMBL | Assay Description Inhibition of PDE8A1 catalytic domain (unknown origin) using [3H]-cGMP/[3H]-cAMP as substrate after 15 mins by liquid scintillation counting analysis | J Med Chem 57: 10304-13 (2014) Article DOI: 10.1021/jm500836h BindingDB Entry DOI: 10.7270/Q28P624W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM50034647 (CHEMBL3360412) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 141 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-Sen University Curated by ChEMBL | Assay Description Inhibition of PDE5A1 catalytic domain (unknown origin) using [3H]-cGMP/[3H]-cAMP as substrate after 15 mins by liquid scintillation counting analysis | J Med Chem 57: 10304-13 (2014) Article DOI: 10.1021/jm500836h BindingDB Entry DOI: 10.7270/Q28P624W | |||||||||||
More data for this Ligand-Target Pair |