BDBM50034828 8-Ethoxy-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid ethyl ester::CHEMBL416450

SMILES: CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(OCC)ccc-21

InChI Key: InChIKey=CIGLLASOKXAMLS-UHFFFAOYSA-N

Data: 10 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50034828   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
GABA receptor alpha-5/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM50034828 (8-Ethoxy-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tri...) Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(OCC)ccc-21 Show InChI InChI=1S/C17H19N3O4/c1-4-23-11-6-7-13-12(8-11)16(21)19(3)9-14-15(17(22)24-5-2)18-10-20(13)14/h6-8,10H,4-5,9H2,1-3H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-5-beta-3-gamma-2				J Med Chem 43: 71-95 (2000) BindingDB Entry DOI: 10.7270/Q2W37X0J
					More data for this Ligand-Target Pair
GABA receptor alpha-5/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM50034828 (8-Ethoxy-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tri...) Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(OCC)ccc-21 Show InChI InChI=1S/C17H19N3O4/c1-4-23-11-6-7-13-12(8-11)16(21)19(3)9-14-15(17(22)24-5-2)18-10-20(13)14/h6-8,10H,4-5,9H2,1-3H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description Binding affinity for Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2				J Med Chem 41: 4130-42 (1998) Article DOI: 10.1021/jm980317y BindingDB Entry DOI: 10.7270/Q2W37VFJ
					More data for this Ligand-Target Pair
GABA receptor alpha-1/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM50034828 (8-Ethoxy-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tri...) Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(OCC)ccc-21 Show InChI InChI=1S/C17H19N3O4/c1-4-23-11-6-7-13-12(8-11)16(21)19(3)9-14-15(17(22)24-5-2)18-10-20(13)14/h6-8,10H,4-5,9H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-1-beta-3-gamma-2				J Med Chem 43: 71-95 (2000) BindingDB Entry DOI: 10.7270/Q2W37X0J
					More data for this Ligand-Target Pair
GABA receptor alpha-1/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM50034828 (8-Ethoxy-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tri...) Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(OCC)ccc-21 Show InChI InChI=1S/C17H19N3O4/c1-4-23-11-6-7-13-12(8-11)16(21)19(3)9-14-15(17(22)24-5-2)18-10-20(13)14/h6-8,10H,4-5,9H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description Binding affinity against alpha1-beta3-gamma2 GABAA/BzR receptor subtype.				J Med Chem 41: 4130-42 (1998) Article DOI: 10.1021/jm980317y BindingDB Entry DOI: 10.7270/Q2W37VFJ
					More data for this Ligand-Target Pair
GABA receptor alpha-3/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM50034828 (8-Ethoxy-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tri...) Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(OCC)ccc-21 Show InChI InChI=1S/C17H19N3O4/c1-4-23-11-6-7-13-12(8-11)16(21)19(3)9-14-15(17(22)24-5-2)18-10-20(13)14/h6-8,10H,4-5,9H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	17	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description Binding affinity against alpha3-beta3-gamma2 GABAA/BzR receptor subtype.				J Med Chem 41: 4130-42 (1998) Article DOI: 10.1021/jm980317y BindingDB Entry DOI: 10.7270/Q2W37VFJ
					More data for this Ligand-Target Pair
GABA receptor alpha-3/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM50034828 (8-Ethoxy-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tri...) Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(OCC)ccc-21 Show InChI InChI=1S/C17H19N3O4/c1-4-23-11-6-7-13-12(8-11)16(21)19(3)9-14-15(17(22)24-5-2)18-10-20(13)14/h6-8,10H,4-5,9H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	17	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-3-beta-3-gamma-2				J Med Chem 43: 71-95 (2000) BindingDB Entry DOI: 10.7270/Q2W37X0J
					More data for this Ligand-Target Pair
GABA receptor alpha-2/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM50034828 (8-Ethoxy-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tri...) Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(OCC)ccc-21 Show InChI InChI=1S/C17H19N3O4/c1-4-23-11-6-7-13-12(8-11)16(21)19(3)9-14-15(17(22)24-5-2)18-10-20(13)14/h6-8,10H,4-5,9H2,1-3H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	36	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description Binding affinity to human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-2-beta-3-gamma-2				J Med Chem 43: 71-95 (2000) BindingDB Entry DOI: 10.7270/Q2W37X0J
					More data for this Ligand-Target Pair
GABA receptor alpha-2/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM50034828 (8-Ethoxy-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tri...) Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(OCC)ccc-21 Show InChI InChI=1S/C17H19N3O4/c1-4-23-11-6-7-13-12(8-11)16(21)19(3)9-14-15(17(22)24-5-2)18-10-20(13)14/h6-8,10H,4-5,9H2,1-3H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	36	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description Binding affinity of the compound tested against alpha2-beta3-gamma2 GABAA/BzR receptor subtype.				J Med Chem 41: 4130-42 (1998) Article DOI: 10.1021/jm980317y BindingDB Entry DOI: 10.7270/Q2W37VFJ
					More data for this Ligand-Target Pair
GABA receptor alpha-6/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM50034828 (8-Ethoxy-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tri...) Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(OCC)ccc-21 Show InChI InChI=1S/C17H19N3O4/c1-4-23-11-6-7-13-12(8-11)16(21)19(3)9-14-15(17(22)24-5-2)18-10-20(13)14/h6-8,10H,4-5,9H2,1-3H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	52	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description Binding affinity against Gamma-aminobutyric-acid A receptor alpha6-beta3-gamma2				J Med Chem 41: 4130-42 (1998) Article DOI: 10.1021/jm980317y BindingDB Entry DOI: 10.7270/Q2W37VFJ
					More data for this Ligand-Target Pair
GABA receptor alpha-6/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM50034828 (8-Ethoxy-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tri...) Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(OCC)ccc-21 Show InChI InChI=1S/C17H19N3O4/c1-4-23-11-6-7-13-12(8-11)16(21)19(3)9-14-15(17(22)24-5-2)18-10-20(13)14/h6-8,10H,4-5,9H2,1-3H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	52	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2				J Med Chem 43: 71-95 (2000) BindingDB Entry DOI: 10.7270/Q2W37X0J
					More data for this Ligand-Target Pair