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BDBM50034847 5-Biphenyl-4-yl-2-biphenyl-4-ylmethyl-4-(2-carboxy-ethylcarbamoyl)-pentanoic acid::CHEMBL49430

SMILES: OC(=O)CCNC(=O)C(CC(Cc1ccc(cc1)-c1ccccc1)C(O)=O)Cc1ccc(cc1)-c1ccccc1

InChI Key: InChIKey=DWDVHKYYBWXMSS-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50034847   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))		BDBM50034847
PNG
(5-Biphenyl-4-yl-2-biphenyl-4-ylmethyl-4-(2-carboxy...)
Show SMILES OC(=O)CCNC(=O)C(CC(Cc1ccc(cc1)-c1ccccc1)C(O)=O)Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C34H33NO5/c36-32(37)19-20-35-33(38)30(21-24-11-15-28(16-12-24)26-7-3-1-4-8-26)23-31(34(39)40)22-25-13-17-29(18-14-25)27-9-5-2-6-10-27/h1-18,30-31H,19-23H2,(H,35,38)(H,36,37)(H,39,40)
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n/an/a 49n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
In vitro inhibition of rat neutral endopeptidase by using GAAP as substrate

J Med Chem 38: 1689-700 (1995)


BindingDB Entry DOI: 10.7270/Q2Z89BD0
More data for this
Ligand-Target Pair