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BDBM50034849 4-(2-Carboxy-ethylcarbamoyl)-2-(4-thiazol-2-yl-benzyl)-5-(4-thiazol-2-yl-phenyl)-pentanoic acid::CHEMBL47493

SMILES: OC(=O)CCNC(=O)C(CC(Cc1ccc(cc1)-c1nccs1)C(O)=O)Cc1ccc(cc1)-c1nccs1

InChI Key: InChIKey=IWPUQZBZQQVKRL-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50034849   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neprilysin


(Rattus norvegicus (Rat))		BDBM50034849
PNG
(4-(2-Carboxy-ethylcarbamoyl)-2-(4-thiazol-2-yl-ben...)
Show SMILES OC(=O)CCNC(=O)C(CC(Cc1ccc(cc1)-c1nccs1)C(O)=O)Cc1ccc(cc1)-c1nccs1
Show InChI InChI=1S/C28H27N3O5S2/c32-24(33)9-10-29-25(34)22(15-18-1-5-20(6-2-18)26-30-11-13-37-26)17-23(28(35)36)16-19-3-7-21(8-4-19)27-31-12-14-38-27/h1-8,11-14,22-23H,9-10,15-17H2,(H,29,34)(H,32,33)(H,35,36)
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PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
In vitro inhibition of rat neutral endopeptidase by using GAAP as substrate

J Med Chem 38: 1689-700 (1995)


BindingDB Entry DOI: 10.7270/Q2Z89BD0
More data for this
Ligand-Target Pair